FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2610869507> ?p ?o ?g. }

• W2610869507 endingPage "349" @default.
• W2610869507 startingPage "338" @default.
• W2610869507 abstract "Gastritis is preponderantly characterized by inflammation of the lining epithelial layer and the chronic gastritis is considered as a pre-cancer lesion. For many centuries olive (Olea europaea) leaf has been used for its putative health potential, nonetheless, to date, the gastroprotective effects of olive leaves have not been studied yet. Hence, in this study we investigated whether olive leaf extract (OLE) could protect gastric mucosa against HCl/ethanol-induced gastric mucosal damage in rats. Hcl/ethanol administration caused significant damage to the gastric mucosa, as confirmed by gastric ulcer index and histological evaluation. However, this damage was largely prevented by pre-administering 20 mg/kg omeprazole or 100 mg/kg OLE. Interestingly, the damage was completely prevented by pre-administering 200 and 300 mg/kg OLE. Moreover, OLE attenuated the inflammatory response by decreasing nuclear factor-κB (NF-κB), cycloxygenase-2 (COX-2) and tumor necrosis factor-α (TNF-α) expressions, and down-regulating inducible nitric oxide synthase (iNOS) and interleukin-1β (IL-1β) in gastric mucosa. The gastroprotective mechanism of OLE involved the promotion of enzymatic and nonenzymatic molecules (superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and glutathione reduced form), promoting nuclear factor erythroid 2-related factor 2 (Nrf2) mRNA expression, halting lipid peroxidation and preventing the overproduction of nitric oxide. Together, our findings clearly demonstrated that OLE could prevent HCl/ethanol-induced gastritis by attenuating inflammation and oxidant/antioxidant imbalance. Indeed, OLE could potentially be useful as a natural therapy for gastritis." @default.
• W2610869507 created "2017-05-12" @default.
• W2610869507 creator A5004985231 @default.
• W2610869507 creator A5021659356 @default.
• W2610869507 creator A5031761453 @default.
• W2610869507 creator A5086923688 @default.
• W2610869507 date "2017-07-01" @default.
• W2610869507 modified "2023-10-15" @default.
• W2610869507 title "Olive ( Olea europaea ) leaf methanolic extract prevents HCl/ethanol-induced gastritis in rats by attenuating inflammation and augmenting antioxidant enzyme activities" @default.
• W2610869507 cites W1580399005 @default.
• W2610869507 cites W1580607327 @default.
• W2610869507 cites W1775749144 @default.
• W2610869507 cites W191793640 @default.
• W2610869507 cites W1924602449 @default.
• W2610869507 cites W1974911740 @default.
• W2610869507 cites W1976538114 @default.
• W2610869507 cites W1983310681 @default.
• W2610869507 cites W1987723637 @default.
• W2610869507 cites W1990802251 @default.
• W2610869507 cites W1991775006 @default.
• W2610869507 cites W1992915344 @default.
• W2610869507 cites W1994371028 @default.
• W2610869507 cites W1994866392 @default.
• W2610869507 cites W2009339344 @default.
• W2610869507 cites W2012450448 @default.
• W2610869507 cites W2020358486 @default.
• W2610869507 cites W2023618700 @default.
• W2610869507 cites W2044736317 @default.
• W2610869507 cites W2046372532 @default.
• W2610869507 cites W2053685416 @default.
• W2610869507 cites W2061082165 @default.
• W2610869507 cites W2062944717 @default.
• W2610869507 cites W2063576996 @default.
• W2610869507 cites W2075274615 @default.
• W2610869507 cites W2098278323 @default.
• W2610869507 cites W2099544466 @default.
• W2610869507 cites W2108248889 @default.
• W2610869507 cites W2127632638 @default.
• W2610869507 cites W2154031058 @default.
• W2610869507 cites W2155208388 @default.
• W2610869507 cites W2157333322 @default.
• W2610869507 cites W2164308626 @default.
• W2610869507 cites W2168544106 @default.
• W2610869507 cites W2295024784 @default.
• W2610869507 cites W2312350979 @default.
• W2610869507 cites W2396191616 @default.
• W2610869507 cites W2422255637 @default.
• W2610869507 cites W2468468421 @default.
• W2610869507 cites W2516968175 @default.
• W2610869507 cites W2558198988 @default.
• W2610869507 doi "https://doi.org/10.1016/j.biopha.2017.04.069" @default.
• W2610869507 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28463797" @default.
• W2610869507 hasPublicationYear "2017" @default.
• W2610869507 type Work @default.
• W2610869507 sameAs 2610869507 @default.
• W2610869507 citedByCount "69" @default.
• W2610869507 countsByYear W26108695072017 @default.
• W2610869507 countsByYear W26108695072018 @default.
• W2610869507 countsByYear W26108695072019 @default.
• W2610869507 countsByYear W26108695072020 @default.
• W2610869507 countsByYear W26108695072021 @default.
• W2610869507 countsByYear W26108695072022 @default.
• W2610869507 countsByYear W26108695072023 @default.
• W2610869507 crossrefType "journal-article" @default.
• W2610869507 hasAuthorship W2610869507A5004985231 @default.
• W2610869507 hasAuthorship W2610869507A5021659356 @default.
• W2610869507 hasAuthorship W2610869507A5031761453 @default.
• W2610869507 hasAuthorship W2610869507A5086923688 @default.
• W2610869507 hasConcept C151730666 @default.
• W2610869507 hasConcept C165069038 @default.
• W2610869507 hasConcept C178790620 @default.
• W2610869507 hasConcept C181199279 @default.
• W2610869507 hasConcept C185592680 @default.
• W2610869507 hasConcept C203014093 @default.
• W2610869507 hasConcept C203565725 @default.
• W2610869507 hasConcept C2775838275 @default.
• W2610869507 hasConcept C2776914184 @default.
• W2610869507 hasConcept C2777622882 @default.
• W2610869507 hasConcept C2778004101 @default.
• W2610869507 hasConcept C2778677798 @default.
• W2610869507 hasConcept C2778760513 @default.
• W2610869507 hasConcept C2778979269 @default.
• W2610869507 hasConcept C2779422922 @default.
• W2610869507 hasConcept C2780073392 @default.
• W2610869507 hasConcept C2780829032 @default.
• W2610869507 hasConcept C2781397471 @default.
• W2610869507 hasConcept C2781443798 @default.
• W2610869507 hasConcept C519581460 @default.
• W2610869507 hasConcept C538909803 @default.
• W2610869507 hasConcept C55493867 @default.
• W2610869507 hasConcept C71924100 @default.
• W2610869507 hasConcept C86803240 @default.
• W2610869507 hasConcept C98274493 @default.
• W2610869507 hasConceptScore W2610869507C151730666 @default.
• W2610869507 hasConceptScore W2610869507C165069038 @default.
• W2610869507 hasConceptScore W2610869507C178790620 @default.
• W2610869507 hasConceptScore W2610869507C181199279 @default.
• W2610869507 hasConceptScore W2610869507C185592680 @default.

• next