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- W2610891751 abstract "Onchocerciasis is a major cause of blindness worldwide, and much of the blindness is caused by onchocercal chorioretinitis. In an experimental animal model for ocular onchocerciasis, intravitreal injections of 10,000 live Onchocerca volvulus microfilariae isolated from infected humans into the eyes of cynomolgus monkeys (Macaca fascicularis) resulted in patchy, progressive loss of retinal pigment with pigment clumping. Areas of pigment loss were less extensive in animals that had been sensitized with microfilariae. Intravitreal injections of dead O. volvulus microfilariae resulted in mild vitritis with relatively less clinical change noted in the retina and choroid. Histopathologic examination revealed thinning and loss of outer retinal layers with pigment migration into the retina, and inflammation was more pronounced in eyes that received live microfilariae. Clinical changes appeared in eyes receiving live microfilariae before the development of significant antibody or cell-mediated immune responses. O. volvulus microfilariae appear to be more suitable than O. lienalis microfilariae in producing lesions which resemble human onchocerciasis in the primate model. Invest Ophthalmol Vis Sci 32:14991507,1991 Onchocerciasis, a filarial infection caused by Onchocerca volvulus, affects more than 18 million people worldwide 1 and is a leading cause of blindness. A characteristic chorioretinitis and chorioretinal scarring account for nearly one half of this blindness. The pathogenesis of the fundus lesion is unclear in part due to the scarcity of affected human eyes for pathologic studies and the lack of detailed longitudinal ophthalmologic study of affected patients. An experimental animal model using intravitreal injections of O. lienalis microfilariae in cynomolgus monkeys recently facilitated the study of the immunopathology and pathogenesis of onchocercal chorioretinitis. 2 4 Chorioretinal changes, including retinal pig" @default.
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- W2610891751 date "1991-01-01" @default.
- W2610891751 modified "2023-09-23" @default.
- W2610891751 title "Experimental Ocular Onchocerciasis in Cynomolgus Monkeys IV. Chorioreriniris Elicited by Onchocerca volvulus Microfilariae" @default.
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