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- W2610988718 abstract "In general, donor lymphocyte infusions (DLIs) are more likely to be successful in eradicating minimal amounts of disease. New or worsening graft-versus-host-disease (GvHD) has been a limiting side effect of DLI. The lymphocytes used as a DLI may be either newly acquired from the donor by additional lymphapheresis or can be in an aliquot of mobilized peripheral blood hematopoietic progenitor cells not used in the original transplant. The number of DLIs any patient will receive is limited by one of the following factors: the number of donor products available, the subsequent occurrence of GvHD, a response, or progression of the disease despite the DLI. As DLI is used to treat relapse, the situation in which any DLI is given is necessarily individualized to the needs of a specific patient. DLI in myeloma has suffered from the same apparent limitations as allogeneic hematopoietic cell transplant itself for myeloma with a distinct lack of predictable graft-versus-tumor effects." @default.
- W2610988718 created "2017-05-12" @default.
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- W2610988718 date "2017-05-06" @default.
- W2610988718 modified "2023-10-12" @default.
- W2610988718 title "Donor lymphocyte infusion" @default.
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- W2610988718 doi "https://doi.org/10.1002/9781119095491.ch36" @default.
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