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• W2610994169 abstract "Aim: The treatment of non-small-cell lung cancer has changed after the development of the immune checkpoint inhibitors. Although the most studied biomarker is PD-L1 expression, its clinical significance is still debatable. In this article, we show the updated survival analysis of all published data. Methods: We searched in network and conference data sources for relevant clinical studies of immunotherapy for non-small-cell lung cancer that assessed the PD-L1 expression even as an exploratory analysis. The updated survival hazard ratios (HR) were included in the analysis. Results: 14 studies with 2857 patients were included (2019 treated with immunotherapy). The response rate was as higher among PD-L1-positive patients (RR: 2.19, 95% CI: 1.63–2.94). PD-L1 expression was also related to better progression-free survival (HR: 0.69, 95% CI: 0.57–0.85) and better overall survival (HR: 0.77, 95% CI: 0.67–0.89). Conclusion: PD-L1 overexpression predicts activity as well as better survival for patients treated with immune checkpoint inhibitors." @default.
• W2610994169 created "2017-05-12" @default.
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• W2610994169 date "2017-05-01" @default.
• W2610994169 modified "2023-10-16" @default.
• W2610994169 title "PD-L1 expression as a predictive biomarker in advanced non-small-cell lung cancer: updated survival data" @default.
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• W2610994169 doi "https://doi.org/10.2217/imt-2016-0150" @default.
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