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• W2610996896 startingPage "30" @default.
• W2610996896 abstract "The pathophysiological hypothesis underlying tic disorders in Tourette syndrome (TS) is that basal ganglia are not capable of properly filtering cortical information, leading patients with difficulties in inhibiting unwanted behaviors or impulses. One of the main challenges for furthering such a hypothesis is to find appropriate animal models summarizing some aspects of the disease. It has been established for more than 25 years in rodents that the prototypical serotonin (5-HT) agonist meta-chlorophenylpiperazine (m-CPP) elicits purposeless oral movements including chewing behavior. These bouts of oral movements, originally thought to mimic human oral dyskinesia consequent to long-term administration of antipsychotic drugs or parkinsonian tremor, could correspond to an undefined form of tics. Here, we describe the nature of the purposeless oral movements triggered by m-CPP and other agonists which could be associated with obsessive compulsive disorders. We report the pharmacology of this response with a focus on the 5-HT2C receptor subtype and the degree to which the dopaminergic and cholinergic systems are involved. The orofacial dyskinetic effects are related to the action of these compounds in associative/limbic territories of the basal ganglia, rather than sensorimotor ones, as expected from the human disease. In spite of the low translational value of these oral movements, the neurobiological analysis of these oral movements could help to a better understanding of the pathophysiology of tics and compulsive disorders often cormorbid with TS." @default.
• W2610996896 created "2017-05-12" @default.
• W2610996896 creator A5049697442 @default.
• W2610996896 creator A5084849836 @default.
• W2610996896 date "2017-12-01" @default.
• W2610996896 modified "2023-09-25" @default.
• W2610996896 title "Purposeless oral activity induced by meta -chlorophenylpiperazine (m-CPP): Undefined tic-like behaviors?" @default.
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• W2610996896 doi "https://doi.org/10.1016/j.jneumeth.2017.05.007" @default.
• W2610996896 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28483714" @default.
• W2610996896 hasPublicationYear "2017" @default.
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