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• W2611075837 abstract "We studied the effect of 1,25(OH)2D3 (vitamin D3) on intracellular chemokine-positive T-cell subsets in whole blood cultures of healthy controls and patients with pulmonary tuberculosis.Genotyping was performed by the polymerase chain reaction-restriction fragment length polymorphism method. The regulatory role of the Cdx2 and 3'UTR TaqI gene variants on chemokine-positive T-cell subsets was studied from culture filtrate antigen stimulated with or without vitamin D3 treated whole blood cultures of 60 healthy controls and 50 patients with pulmonary tuberculosis.Vitamin D3 significantly suppressed monocyte chemoattractant protein 1, macrophage inhibitory protein (MIP)-1α, MIP-1β, regulated on activation, normal T-cell expressed and secreted (RANTES), and interferon-γ inducible protein 10 (IP-10)-positive T-cell subsets compared with culture filtrate antigen stimulated cells without vitamin D3 treatment. In the Cdx2 AA genotype, vitamin D3 decreased MIP-1α, MIP-1β, and RANTES-positive T cells compared with the GG genotype. Whereas in the TaqI tt genotype, decreased MIP-1β and RANTES and increased IP-10-positive T cells were observed compared with the TT genotype in vitamin D3 treated cells (p < 0.05).This study suggests that vitamin D3 may regulate the chemokine-positive T cells through the Cdx2 AA and TaqI tt genotypes. This could be helpful to regulate chemokine-mediated inflammatory response during active disease condition. Hence, vitamin D3 supplementation along with tuberculosis drugs may be useful for faster recovery from the disease." @default.
• W2611075837 created "2017-05-12" @default.
• W2611075837 creator A5039492176 @default.
• W2611075837 creator A5047318755 @default.
• W2611075837 date "2017-05-01" @default.
• W2611075837 modified "2023-09-27" @default.
• W2611075837 title "Influence of Cdx2 and TaqI Gene Variants on Vitamin D 3 Modulated Intracellular Chemokine Positive T-Cell Subsets in Pulmonary Tuberculosis" @default.
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• W2611075837 doi "https://doi.org/10.1016/j.clinthera.2017.04.003" @default.
• W2611075837 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28476406" @default.
• W2611075837 hasPublicationYear "2017" @default.
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