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• W2611080650 abstract "Jawad Ahmed 1 *, Nisar Ahmad 2 , Liaqat Ali 2 , Hamid Hussain 3 and Abid Sohail Taj 1 1 Institute of Basic Medical Sciences, KMU, Peshawar 2 Department of Pathology, Khyber Medical College, Peshawar 3 Department of Community Medicine and Public Health, KMC, Peshawar Background: Tuberculosis, caused by M. tuberculosis is a disease of greater antiquity that has been declared as global emergency by WHO. It is one of the oldest, chronic granulomatous diseases of mankind (1). Lungs are the primary site of infection in humans but any organ (except nail and hair) can be infected causing extra pulmonary tuberculosis (2). Morbidity and mortality due to tuberculosis continues to rise because of deteriorating health care facilities in developing countries (3). The emergence of multidrug-resistant tuberculosis (MDR-TB) is a significant obstacle to the control of this disease because it makes the treatment more complex as well as costly. Methodology: Prevalence of drug resistance was estimated in positive culture isolates of patients attending a District Tuberculosis Office (DTO) in Peshawar from Jan 2008 – Jun 2008. Results: Of the 751 patients attending the clinic in Peshawar, 424 patients were diagnosed with pulmonary tuberculosis,313 (73.8%) were confirmed as smear positive, while 142 (33.5%) sputum specimens were culture positive. 180 (42.5%) were male and 244 (57.5%) were female. Majority of resistance was to streptomycin 37.3% and isoniazid 33.8%. A total of 30 (12.12%) patients had MDR-TBas defined by resistance to isoniazid and rifampicin both. Of the 30 patients, 21 (70%) were female and 9 were male (30%). 2.7% of the MDR cases were recorded in new patients while 13.8% were observed in already treated relapsed patients. 50% of the MDR-TB cases were in the 25-60 years age group. Overall prevalence of MDR-TB cases was 7.08%. Conclusions: Considerable resistance was observed to the first-line ant-tuberculosis drugs, like isoniazid, rifampicin, ethambutol, streptomycin and pyrazinamide. Significant difference was observed between male and female (30 to 70%) MDR-TB cases due to lack of education, local customs preventing them from access to health care centers. Poor awareness of people regarding TB treatment and inappropriate physicians’ prescription are important influencing factors promoting MDR-TB in these areas. TB surveillance and DOTS therapy program should be made available in remote regions of the province. Key Words: Mycobacterium tuberculosis , Drug resistance, MDR-TB, Peshawar Address of corresponding author: * Prof Dr Jawad Ahmed Director/Professor of Microbiology Institute of Basic Medical Sciences, Khyber Medical University, Peshawar j62ahmed@yahoo.com" @default.
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• W2611080650 date "2015-02-05" @default.
• W2611080650 modified "2023-09-27" @default.
• W2611080650 title "MULTIDRUG RESISTANT MYCOBACTERIUM TUBERCULOSIS STRAINS IN PESHAWAR, PAKISTAN" @default.
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