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- W2611117795 abstract "Glucocorticoid receptor-α (GRα) and peroxisome proliferator–activated receptor-γ (PPARγ) are critical regulators of adipogenic responses. We have shown that FK506-binding protein 51 (FKBP51) represses the Akt-p38 kinase pathway to reciprocally inhibit GRα but stimulate PPARγ by targeting serine 112 (PPARγ) and serines 220 and 234 (GRα). Here, this mechanism is shown to be essential for GRα and PPARγ control of cellular adipogenesis. In 3T3-L1 cells, FKBP51 was a prominent marker of the differentiated state and knockdown of FKBP51 showed reduced lipid accumulation and expression of adipogenic genes. Compared with wild-type (WT), FKBP51 knockout (51KO) mouse embryonic fibroblasts (MEFs) showed dramatic resistance to differentiation, with almost no lipid accumulation and greatly reduced adipogenic gene expression. These features were rescued by reexpression of FKBP51 in 51KO cells. 51KO MEFs exhibited reduced fatty acid synthase activity, increased sensitivity to GRα-induced lipolysis, and reduced PPARγ acti..." @default.
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- W2611117795 date "2014-08-01" @default.
- W2611117795 modified "2023-09-26" @default.
- W2611117795 title "FKBP51 controls cellular adipogenesis through p38 kinase-mediated phosphorylation of GRα and PPARγ" @default.
- W2611117795 hasPublicationYear "2014" @default.
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