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- W2611350779 abstract "Primary or post ET/PV myelofibrosis is one of the Philadelphia-negative myeloproliferative neoplasms (MPN) with worst survival rates. This chapter summarizes available data and presents recommendations that are mainly derived from an international expert panel from European Society of Blood and Marrow Transplantation (EBMT) and European Leukemia Net (ELN) with respect to indication and performing allogeneic hematopoietic cell transplantation (allo-HCT) in patients with myelofibrosis. Bone marrow fibrosis is a hallmark of the disease. The fibrogenesis is believed to be caused by cytokines such as platelet-derived growth factor (PDGF), beta-fibro-blast-derived growth factor (p-FGF), or/transforming growth factor p (TGF-p) secreted from clonal megakaryocytes, and/or clonal monocyte/histiocyte proliferation. Cord blood transplantation is associated with high risk of graft failure. More recently, use of HLA-haploidentical donors by preventing GvHD by post-transplant cyclophosphamide has been a more frequently used alternative donor source for hematological malignancies but systematic investigations for myelofi-brosis are lacking so far." @default.
- W2611350779 created "2017-05-12" @default.
- W2611350779 creator A5001646221 @default.
- W2611350779 date "2017-05-06" @default.
- W2611350779 modified "2023-10-12" @default.
- W2611350779 title "Philadelphia chromosome negative myeloproliferative neoplasms" @default.
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- W2611350779 doi "https://doi.org/10.1002/9781119095491.ch14" @default.
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