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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2611387788> ?p ?o ?g. }

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• W2611387788 abstract "17β-Hydroxysteroid dehydrogenase type 2 (17β-HSD2) converts the potent estrogen estradiol into the weakly active keto form estrone. Because of its expression in bone, inhibition of 17β-HSD2 provides an attractive strategy for the treatment of osteoporosis, a condition that is often caused by a decrease of the active sex steroids. Currently, there are no drugs on the market targeting 17β-HSD2, but in multiple studies, synthesis and biological evaluation of promising 17β-HSD2 inhibitors have been reported. Our previous work led to the identification of phenylbenzenesulfonamides and -sulfonates as new 17β-HSD2 inhibitors by ligand-based pharmacophore modeling and virtual screening. In this study, new molecules representing this scaffold were synthesized and tested in vitro for their 17β-HSD2 activity to derive more profound structure-activity relationship rules." @default.
• W2611387788 created "2017-05-12" @default.
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• W2611387788 date "2017-07-01" @default.
• W2611387788 modified "2023-09-26" @default.
• W2611387788 title "Phenylbenzenesulfonates and -sulfonamides as 17β-hydroxysteroid dehydrogenase type 2 inhibitors: Synthesis and SAR-analysis" @default.
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• W2611387788 doi "https://doi.org/10.1016/j.bmcl.2017.05.005" @default.
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