Matches in SemOpenAlex for { <https://semopenalex.org/work/W2611412037> ?p ?o ?g. }
- W2611412037 endingPage "30" @default.
- W2611412037 startingPage "19" @default.
- W2611412037 abstract "Indole alkaloids possess a large spectrum of biological activities including anti-protozoal action. Here we report for the first time that voacamine, isolated from the plant Tabernaemontana coronaria, is an antiprotozoal agent effective against a large array of trypanosomatid parasites including Indian strain of Leishmania donovani and Brazilian strains of Leishmania amazonensis and Trypanosoma cruzi. It inhibits the relaxation activity of topoisomerase IB of L. donovani (LdTop1B) and stabilizes the cleavable complex. Voacamine is probably the first LdTop1B-specific poison to act uncompetitively. It has no impact on human topoisomerase I and II up to 200μM concentrations. The study also provides a thorough insight into ultrastructural alterations induced in three kinetoplastid parasites by a specific inhibitor of LdTop1B. Voacamine is also effective against intracellular amastigotes of different drug unresponsive field isolates of Leishmania donovani obtained from endemic zones of India severely affected with visceral leishmaniasis. Most importantly, this is the first report demonstrating the efficacy of a compound to reduce the burden of drug resistant parasites, unresponsive to SAG, amphotericin B and miltefosine, in experimental BALB/c mice model of visceral leishmaniasis. The findings cumulatively provide a strong evidence that voacamine can be a promising drug candidate against trypanosomatid infections." @default.
- W2611412037 created "2017-05-12" @default.
- W2611412037 creator A5005151809 @default.
- W2611412037 creator A5006188921 @default.
- W2611412037 creator A5007905696 @default.
- W2611412037 creator A5008388681 @default.
- W2611412037 creator A5014123016 @default.
- W2611412037 creator A5021718033 @default.
- W2611412037 creator A5028366364 @default.
- W2611412037 creator A5035399339 @default.
- W2611412037 creator A5039375363 @default.
- W2611412037 creator A5048024223 @default.
- W2611412037 creator A5054138064 @default.
- W2611412037 creator A5055196554 @default.
- W2611412037 creator A5059199694 @default.
- W2611412037 creator A5060627892 @default.
- W2611412037 date "2017-08-01" @default.
- W2611412037 modified "2023-10-16" @default.
- W2611412037 title "Voacamine alters Leishmania ultrastructure and kills parasite by poisoning unusual bi-subunit topoisomerase IB" @default.
- W2611412037 cites W13366111 @default.
- W2611412037 cites W1536203824 @default.
- W2611412037 cites W1543261346 @default.
- W2611412037 cites W1627971854 @default.
- W2611412037 cites W1730123569 @default.
- W2611412037 cites W1899286218 @default.
- W2611412037 cites W1965617271 @default.
- W2611412037 cites W1973958258 @default.
- W2611412037 cites W1975857039 @default.
- W2611412037 cites W1978129773 @default.
- W2611412037 cites W1981360759 @default.
- W2611412037 cites W2005302972 @default.
- W2611412037 cites W2020216656 @default.
- W2611412037 cites W2020661761 @default.
- W2611412037 cites W2028727595 @default.
- W2611412037 cites W2031722061 @default.
- W2611412037 cites W2043990009 @default.
- W2611412037 cites W2045203645 @default.
- W2611412037 cites W2048434556 @default.
- W2611412037 cites W2067332276 @default.
- W2611412037 cites W2068431216 @default.
- W2611412037 cites W2074030379 @default.
- W2611412037 cites W2074505948 @default.
- W2611412037 cites W2079756332 @default.
- W2611412037 cites W2080024797 @default.
- W2611412037 cites W2082895427 @default.
- W2611412037 cites W2084164203 @default.
- W2611412037 cites W2087915958 @default.
- W2611412037 cites W2089148248 @default.
- W2611412037 cites W2095355415 @default.
- W2611412037 cites W2103489107 @default.
- W2611412037 cites W2114457715 @default.
- W2611412037 cites W2130685702 @default.
- W2611412037 cites W2132600317 @default.
- W2611412037 cites W2137978386 @default.
- W2611412037 cites W2140056038 @default.
- W2611412037 cites W2141276562 @default.
- W2611412037 cites W2146274229 @default.
- W2611412037 cites W2152855843 @default.
- W2611412037 cites W2168350246 @default.
- W2611412037 cites W2171043246 @default.
- W2611412037 cites W2172419694 @default.
- W2611412037 cites W2335276322 @default.
- W2611412037 cites W4236530034 @default.
- W2611412037 doi "https://doi.org/10.1016/j.bcp.2017.05.002" @default.
- W2611412037 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28483460" @default.
- W2611412037 hasPublicationYear "2017" @default.
- W2611412037 type Work @default.
- W2611412037 sameAs 2611412037 @default.
- W2611412037 citedByCount "29" @default.
- W2611412037 countsByYear W26114120372018 @default.
- W2611412037 countsByYear W26114120372019 @default.
- W2611412037 countsByYear W26114120372020 @default.
- W2611412037 countsByYear W26114120372021 @default.
- W2611412037 countsByYear W26114120372022 @default.
- W2611412037 countsByYear W26114120372023 @default.
- W2611412037 crossrefType "journal-article" @default.
- W2611412037 hasAuthorship W2611412037A5005151809 @default.
- W2611412037 hasAuthorship W2611412037A5006188921 @default.
- W2611412037 hasAuthorship W2611412037A5007905696 @default.
- W2611412037 hasAuthorship W2611412037A5008388681 @default.
- W2611412037 hasAuthorship W2611412037A5014123016 @default.
- W2611412037 hasAuthorship W2611412037A5021718033 @default.
- W2611412037 hasAuthorship W2611412037A5028366364 @default.
- W2611412037 hasAuthorship W2611412037A5035399339 @default.
- W2611412037 hasAuthorship W2611412037A5039375363 @default.
- W2611412037 hasAuthorship W2611412037A5048024223 @default.
- W2611412037 hasAuthorship W2611412037A5054138064 @default.
- W2611412037 hasAuthorship W2611412037A5055196554 @default.
- W2611412037 hasAuthorship W2611412037A5059199694 @default.
- W2611412037 hasAuthorship W2611412037A5060627892 @default.
- W2611412037 hasConcept C136764020 @default.
- W2611412037 hasConcept C202751555 @default.
- W2611412037 hasConcept C203014093 @default.
- W2611412037 hasConcept C2776027055 @default.
- W2611412037 hasConcept C2776555147 @default.
- W2611412037 hasConcept C2776635100 @default.
- W2611412037 hasConcept C2777625466 @default.
- W2611412037 hasConcept C2778048844 @default.