FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2611422626> ?p ?o ?g. }

• W2611422626 endingPage "145" @default.
• W2611422626 startingPage "136" @default.
• W2611422626 abstract "Diabetes mellitus represents a group of metabolic diseases that are characterized by hyperglycemia caused by either lack of insulin production or a reduced ability to respond to insulin. It is estimated that there were 347 million people worldwide who suffered from diabetes in 2008 and incidence is predicted to double by 2050. Neuropathy is the most common complication of long-term diabetes and approximately 30% of these subjects develop chronic neuropathic pain. A distinct acute, severe form of neuropathic pain, called insulin neuritis or treatment-induced painful neuropathy of diabetes (TIND), may also occur shortly after initiation of intensive glycemic control, with an incidence rate of up to 10.9%. The pathological mechanisms leading to TIND, which is mostly unresponsive to analgesics, are not yet understood, impeding the development of therapies. Studies to date have been clinical and with limited cohorts of patients. In the current study, we developed chronic and acute insulin-induced neuropathic pain in mice with type 2 insulin-resistant diabetes. Furthermore, we determined that insulin-induced acute allodynia is independent of glycemia levels, can also be induced with Insulin-like Growth Factor 1 (IGF1) and be prevented by inhibition of AKT, providing evidence of an insulin/IGF1 signaling pathway-based mechanism for TIND. This mouse model is useful for the elucidation of mechanisms contributing to TIND and for the testing of new therapeutic approaches to treat TIND." @default.
• W2611422626 created "2017-05-12" @default.
• W2611422626 creator A5000934923 @default.
• W2611422626 creator A5008291444 @default.
• W2611422626 creator A5017325935 @default.
• W2611422626 creator A5017590743 @default.
• W2611422626 creator A5043287945 @default.
• W2611422626 date "2017-06-01" @default.
• W2611422626 modified "2023-09-26" @default.
• W2611422626 title "Murine model and mechanisms of treatment-induced painful diabetic neuropathy" @default.
• W2611422626 cites W1609815362 @default.
• W2611422626 cites W1945881325 @default.
• W2611422626 cites W1953598874 @default.
• W2611422626 cites W1968264094 @default.
• W2611422626 cites W1971293263 @default.
• W2611422626 cites W1972974949 @default.
• W2611422626 cites W1973847379 @default.
• W2611422626 cites W1997146974 @default.
• W2611422626 cites W1998108670 @default.
• W2611422626 cites W1998973930 @default.
• W2611422626 cites W2002218454 @default.
• W2611422626 cites W2005982090 @default.
• W2611422626 cites W2007018052 @default.
• W2611422626 cites W2008288388 @default.
• W2611422626 cites W2010740931 @default.
• W2611422626 cites W2027256301 @default.
• W2611422626 cites W2029209464 @default.
• W2611422626 cites W2031677735 @default.
• W2611422626 cites W2033815178 @default.
• W2611422626 cites W2038250511 @default.
• W2611422626 cites W2039784545 @default.
• W2611422626 cites W2040833680 @default.
• W2611422626 cites W2048497026 @default.
• W2611422626 cites W2053773901 @default.
• W2611422626 cites W2060102230 @default.
• W2611422626 cites W2062090790 @default.
• W2611422626 cites W2077343488 @default.
• W2611422626 cites W2079650065 @default.
• W2611422626 cites W2080577282 @default.
• W2611422626 cites W2082855867 @default.
• W2611422626 cites W2083724895 @default.
• W2611422626 cites W2103351070 @default.
• W2611422626 cites W2105040694 @default.
• W2611422626 cites W2107406042 @default.
• W2611422626 cites W2110165605 @default.
• W2611422626 cites W2130189158 @default.
• W2611422626 cites W2150505140 @default.
• W2611422626 cites W2154974174 @default.
• W2611422626 cites W2156593233 @default.
• W2611422626 cites W2162677494 @default.
• W2611422626 cites W2162902338 @default.
• W2611422626 cites W2163568861 @default.
• W2611422626 cites W2166483018 @default.
• W2611422626 cites W2169005776 @default.
• W2611422626 cites W2172201406 @default.
• W2611422626 cites W2418141207 @default.
• W2611422626 cites W2419272154 @default.
• W2611422626 cites W2465414129 @default.
• W2611422626 cites W2573060051 @default.
• W2611422626 cites W4237707841 @default.
• W2611422626 cites W4254000113 @default.
• W2611422626 cites W74386812 @default.
• W2611422626 cites W832234686 @default.
• W2611422626 doi "https://doi.org/10.1016/j.neuroscience.2017.04.036" @default.
• W2611422626 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5501289" @default.
• W2611422626 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28476321" @default.
• W2611422626 hasPublicationYear "2017" @default.
• W2611422626 type Work @default.
• W2611422626 sameAs 2611422626 @default.
• W2611422626 citedByCount "12" @default.
• W2611422626 countsByYear W26114226262018 @default.
• W2611422626 countsByYear W26114226262019 @default.
• W2611422626 countsByYear W26114226262020 @default.
• W2611422626 countsByYear W26114226262021 @default.
• W2611422626 countsByYear W26114226262022 @default.
• W2611422626 countsByYear W26114226262023 @default.
• W2611422626 crossrefType "journal-article" @default.
• W2611422626 hasAuthorship W2611422626A5000934923 @default.
• W2611422626 hasAuthorship W2611422626A5008291444 @default.
• W2611422626 hasAuthorship W2611422626A5017325935 @default.
• W2611422626 hasAuthorship W2611422626A5017590743 @default.
• W2611422626 hasAuthorship W2611422626A5043287945 @default.
• W2611422626 hasBestOaLocation W26114226262 @default.
• W2611422626 hasConcept C126322002 @default.
• W2611422626 hasConcept C134018914 @default.
• W2611422626 hasConcept C177713679 @default.
• W2611422626 hasConcept C2777107010 @default.
• W2611422626 hasConcept C2777180221 @default.
• W2611422626 hasConcept C2779178840 @default.
• W2611422626 hasConcept C2779306644 @default.
• W2611422626 hasConcept C2780473172 @default.
• W2611422626 hasConcept C42219234 @default.
• W2611422626 hasConcept C555293320 @default.
• W2611422626 hasConcept C71924100 @default.
• W2611422626 hasConcept C81182388 @default.
• W2611422626 hasConceptScore W2611422626C126322002 @default.
• W2611422626 hasConceptScore W2611422626C134018914 @default.
• W2611422626 hasConceptScore W2611422626C177713679 @default.

• next