FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2611456245> ?p ?o ?g. }

• W2611456245 endingPage "10949" @default.
• W2611456245 startingPage "10938" @default.
• W2611456245 abstract "The airway epithelium forms a barrier between the internal and external environments. Epithelial dysfunction is critical in the pathology of many respiratory diseases, including cystic fibrosis. Ets homologous factor (EHF) is a key member of the transcription factor network that regulates gene expression in the airway epithelium in response to endogenous and exogenous stimuli. EHF, which has altered expression in inflammatory states, maps to the 5′ end of an intergenic region on Chr11p13 that is implicated as a modifier of cystic fibrosis airway disease. Here we determine the functions of EHF in primary human bronchial epithelial (HBE) cells and relevant airway cell lines. Using EHF ChIP followed by deep sequencing (ChIP-seq) and RNA sequencing after EHF depletion, we show that EHF targets in HBE cells are enriched for genes involved in inflammation and wound repair. Furthermore, changes in gene expression impact cell phenotype because EHF depletion alters epithelial secretion of a neutrophil chemokine and slows wound closure in HBE cells. EHF activates expression of the SAM pointed domain-containing ETS transcription factor, which contributes to goblet cell hyperplasia. Our data reveal a critical role for EHF in regulating epithelial function in lung disease. The airway epithelium forms a barrier between the internal and external environments. Epithelial dysfunction is critical in the pathology of many respiratory diseases, including cystic fibrosis. Ets homologous factor (EHF) is a key member of the transcription factor network that regulates gene expression in the airway epithelium in response to endogenous and exogenous stimuli. EHF, which has altered expression in inflammatory states, maps to the 5′ end of an intergenic region on Chr11p13 that is implicated as a modifier of cystic fibrosis airway disease. Here we determine the functions of EHF in primary human bronchial epithelial (HBE) cells and relevant airway cell lines. Using EHF ChIP followed by deep sequencing (ChIP-seq) and RNA sequencing after EHF depletion, we show that EHF targets in HBE cells are enriched for genes involved in inflammation and wound repair. Furthermore, changes in gene expression impact cell phenotype because EHF depletion alters epithelial secretion of a neutrophil chemokine and slows wound closure in HBE cells. EHF activates expression of the SAM pointed domain-containing ETS transcription factor, which contributes to goblet cell hyperplasia. Our data reveal a critical role for EHF in regulating epithelial function in lung disease." @default.
• W2611456245 created "2017-05-12" @default.
• W2611456245 creator A5015724227 @default.
• W2611456245 creator A5046915316 @default.
• W2611456245 creator A5049641668 @default.
• W2611456245 creator A5058375111 @default.
• W2611456245 creator A5065927229 @default.
• W2611456245 creator A5066839752 @default.
• W2611456245 creator A5081370346 @default.
• W2611456245 creator A5085606046 @default.
• W2611456245 date "2017-06-01" @default.
• W2611456245 modified "2023-10-16" @default.
• W2611456245 title "Ets homologous factor (EHF) has critical roles in epithelial dysfunction in airway disease" @default.
• W2611456245 cites W185124257 @default.
• W2611456245 cites W1964919218 @default.
• W2611456245 cites W1966365711 @default.
• W2611456245 cites W1977830028 @default.
• W2611456245 cites W1980017808 @default.
• W2611456245 cites W1982538300 @default.
• W2611456245 cites W1982820261 @default.
• W2611456245 cites W1988337204 @default.
• W2611456245 cites W1988368673 @default.
• W2611456245 cites W1992213480 @default.
• W2611456245 cites W1997836203 @default.
• W2611456245 cites W2000672459 @default.
• W2611456245 cites W2004817354 @default.
• W2611456245 cites W2014677321 @default.
• W2611456245 cites W2024931422 @default.
• W2611456245 cites W2028130907 @default.
• W2611456245 cites W2033903529 @default.
• W2611456245 cites W2034841786 @default.
• W2611456245 cites W2040025444 @default.
• W2611456245 cites W2040233646 @default.
• W2611456245 cites W2049470707 @default.
• W2611456245 cites W2051249540 @default.
• W2611456245 cites W2057496127 @default.
• W2611456245 cites W2060126259 @default.
• W2611456245 cites W2060729541 @default.
• W2611456245 cites W2061808825 @default.
• W2611456245 cites W2062721883 @default.
• W2611456245 cites W2065473309 @default.
• W2611456245 cites W2067524407 @default.
• W2611456245 cites W2068994162 @default.
• W2611456245 cites W2072036660 @default.
• W2611456245 cites W2073265032 @default.
• W2611456245 cites W2078562541 @default.
• W2611456245 cites W2081096345 @default.
• W2611456245 cites W2082341732 @default.
• W2611456245 cites W2082835152 @default.
• W2611456245 cites W2100305481 @default.
• W2611456245 cites W2101594367 @default.
• W2611456245 cites W2101979131 @default.
• W2611456245 cites W2112986981 @default.
• W2611456245 cites W2113453073 @default.
• W2611456245 cites W2119916715 @default.
• W2611456245 cites W2124578045 @default.
• W2611456245 cites W2125706125 @default.
• W2611456245 cites W2129163745 @default.
• W2611456245 cites W2130017811 @default.
• W2611456245 cites W2131328125 @default.
• W2611456245 cites W2140249435 @default.
• W2611456245 cites W2140551998 @default.
• W2611456245 cites W2147892082 @default.
• W2611456245 cites W2148895280 @default.
• W2611456245 cites W2150850035 @default.
• W2611456245 cites W2154748602 @default.
• W2611456245 cites W2165558354 @default.
• W2611456245 cites W2168602111 @default.
• W2611456245 cites W2206135560 @default.
• W2611456245 cites W2262187954 @default.
• W2611456245 cites W2313722988 @default.
• W2611456245 cites W4210274142 @default.
• W2611456245 cites W4230115907 @default.
• W2611456245 doi "https://doi.org/10.1074/jbc.m117.775304" @default.
• W2611456245 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5491778" @default.
• W2611456245 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28461336" @default.
• W2611456245 hasPublicationYear "2017" @default.
• W2611456245 type Work @default.
• W2611456245 sameAs 2611456245 @default.
• W2611456245 citedByCount "38" @default.
• W2611456245 countsByYear W26114562452017 @default.
• W2611456245 countsByYear W26114562452018 @default.
• W2611456245 countsByYear W26114562452019 @default.
• W2611456245 countsByYear W26114562452020 @default.
• W2611456245 countsByYear W26114562452021 @default.
• W2611456245 countsByYear W26114562452022 @default.
• W2611456245 countsByYear W26114562452023 @default.
• W2611456245 crossrefType "journal-article" @default.
• W2611456245 hasAuthorship W2611456245A5015724227 @default.
• W2611456245 hasAuthorship W2611456245A5046915316 @default.
• W2611456245 hasAuthorship W2611456245A5049641668 @default.
• W2611456245 hasAuthorship W2611456245A5058375111 @default.
• W2611456245 hasAuthorship W2611456245A5065927229 @default.
• W2611456245 hasAuthorship W2611456245A5066839752 @default.
• W2611456245 hasAuthorship W2611456245A5081370346 @default.
• W2611456245 hasAuthorship W2611456245A5085606046 @default.
• W2611456245 hasBestOaLocation W26114562451 @default.
• W2611456245 hasConcept C104317684 @default.

• next