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- W2611509545 abstract "Kaposi’s sarcoma herpesvirus (KSHV) encodes a cluster of twelve micro (mi)RNA precursors, which are abundantly expressed during both latent and lytic infection. Previous studies reported that KSHV is able to inhibit apoptosis; we thus tested the involvement of viral miRNAs in this process. We found that both HEK293 epithelial cells and DG-75 cells stably expressing KSHV miRNAs were protected from apoptosis. Potential cellular targets that were significantly down-regulated upon KSHV miRNAs expression were identified by microarray profiling. Among them, we validated by luciferase reporter assays, quantitative PCR and western blotting Caspase 3 (CASP3), a critical factor for the control of apoptosis. Using site-directed mutagenesis, we found that three KSHV miRNAs, miR-K12-1, 3 and 4-3p, were responsible for the targeting of CASP3. Specific inhibition of these miRNAs in KSHV infected cells resulted in increased expression levels of endogenous CASP3 and enhanced apoptosis. Altogether, our results suggest that KSHV miRNAs directly participate to the previously reported inhibition of apoptosis by the virus, and are thus likely to play a role in KSHV-induced oncogenesis." @default.
- W2611509545 created "2017-05-12" @default.
- W2611509545 creator A5025684536 @default.
- W2611509545 date "2013-05-07" @default.
- W2611509545 modified "2023-09-28" @default.
- W2611509545 title "Regulation of apoptosis by Kaposi’s sarcoma associated herpesvirus microRNAs" @default.
- W2611509545 hasPublicationYear "2013" @default.
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