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• W2611640918 abstract "Oxidative stress has been recognized as a conjoint pathological mechanism that contributes to initiation and progression of liver injury, such as that caused by bacterial diseases. Natural antioxidants are considered a rational curative strategy to prevent and cure hepatic diseases involved with oxidative stress. Thus, the aim of this study was to evaluate, for the first time, whether treatment with bactericidal Melaleuca alternifolia essential oil (TTO) nanoparticles prevents or reduces the hepatic damage in silver catfish (Rhamdia quelen) experimentally infected with Pseudomonas aeruginosa (PAO1). Liver samples from fish infected with P. aeruginosa showed increased thiobarbituric acid reactive substances (TBARS), protein carbonylation and advanced oxidation protein product (AOPP) levels, while catalase (CAT) activity was reduced compared to uninfected animals. The prophylactic treatment with nanoencapsulated TTO prevented these alterations. Based on this evidence, we concluded that P. aeruginosa infection causes hepatic damage, evidenced by increased TBARS, protein carbonylation and AOPP levels, which inhibits the antioxidant defense system, contributing to disease pathophysiology. Thus, this treatment may be considered an important approach for the prevention of hepatic oxidative damage caused by P. aeruginosa infection in fish." @default.
• W2611640918 created "2017-05-12" @default.
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• W2611640918 date "2017-07-01" @default.
• W2611640918 modified "2023-09-24" @default.
• W2611640918 title "Melaleuca alternifolia essential oil nanoparticles ameliorate the hepatic antioxidant/oxidant status of silver catfish experimentally infected with Pseudomonas aeruginosa" @default.
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• W2611640918 doi "https://doi.org/10.1016/j.micpath.2017.05.016" @default.
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