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• W2611700535 abstract "Tedarene A is a macrocyclic diaryl ether heptanoid isolated from the marine sponge Tedania ignis showing an inhibitory effect against nitric oxide production. The first total synthesis of tedarene A was achieved starting from the commercially available 3-(4-methoxyphenyl)propan-1-ol in nine steps and 15.3% overall yield. The synthetic sequence featured an E,Z-dienic bond introduction and a macrocyclization under Ullman conditions. During the synthesis, the E,E-isomer of tedarene A was also obtained and fully characterized." @default.
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• W2611700535 date "2017-05-02" @default.
• W2611700535 modified "2023-10-17" @default.
• W2611700535 title "Total Synthesis of Tedarene A" @default.
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• W2611700535 doi "https://doi.org/10.1021/acs.jnatprod.7b00199" @default.
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