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• W2611763920 abstract "The Zika virus (ZIKV) has emerged as a major health hazard. We present here a high resolution structure (1.55 Å) of ZIKV NS5 methyltransferase bound to a novel S-adenosylmethionine (SAM) analog in which a 4-fluorophenyl moiety substitutes for the methyl group. We show that the 4-fluorophenyl moiety extends into a portion of the RNA binding tunnel that typically contains the adenosine 2'OH of the RNA-cap moiety. Together, the new SAM analog and the high-resolution crystal structure are a step towards the development of antivirals against ZIKV and other flaviviruses." @default.
• W2611763920 created "2017-05-12" @default.
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• W2611763920 date "2017-05-09" @default.
• W2611763920 modified "2023-10-12" @default.
• W2611763920 title "Development of a S-adenosylmethionine analog that intrudes the RNA-cap binding site of Zika methyltransferase" @default.
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• W2611763920 doi "https://doi.org/10.1038/s41598-017-01756-7" @default.
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