FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2611837503> ?p ?o ?g. }

• W2611837503 endingPage "e1114" @default.
• W2611837503 startingPage "e1114" @default.
• W2611837503 abstract "Abstract There is growing evidence that the preconceptual lifestyle and other environmental exposures of a father can significantly alter the physiological and behavioral phenotypes of their children. We and others have shown that paternal preconception stress, regardless of whether the stress was experienced during early-life or adulthood, results in offspring with altered anxiety and depression-related behaviors, attributed to hypothalamic–pituitary–adrenal axis dysregulation. The transgenerational response to paternal preconceptual stress is believed to be mediated by sperm-borne small noncoding RNAs, specifically microRNAs. As physical activity confers physical and mental health benefits for the individual, we used a model of voluntary wheel-running and investigated the transgenerational response to paternal exercise. We found that male offspring of runners had suppressed reinstatement of juvenile fear memory, and reduced anxiety in the light–dark apparatus during adulthood. No changes in these affective behaviors were observed in female offspring. We were surprised to find that running had a limited impact on sperm-borne microRNAs. The levels of three unique microRNAs (miR-19b, miR-455 and miR-133a) were found to be altered in the sperm of runners. In addition, we discovered that the levels of two species of tRNA-derived RNAs (tDRs)—tRNA-Gly and tRNA-Pro—were also altered by running. Taken together, we believe this is the first evidence that paternal exercise is associated with an anxiolytic behavioral phenotype of male offspring and altered levels of small noncoding RNAs in sperm. These small noncoding RNAs are known to have an impact on post-transcriptional gene regulation and can thus change the developmental trajectory of offspring brains and associated affective behaviors." @default.
• W2611837503 created "2017-05-12" @default.
• W2611837503 creator A5012093503 @default.
• W2611837503 creator A5012153148 @default.
• W2611837503 creator A5043282945 @default.
• W2611837503 creator A5050181871 @default.
• W2611837503 creator A5052976583 @default.
• W2611837503 creator A5059332409 @default.
• W2611837503 creator A5078866801 @default.
• W2611837503 creator A5087201875 @default.
• W2611837503 date "2017-05-02" @default.
• W2611837503 modified "2023-10-11" @default.
• W2611837503 title "Exercise alters mouse sperm small noncoding RNAs and induces a transgenerational modification of male offspring conditioned fear and anxiety" @default.
• W2611837503 cites W1587745402 @default.
• W2611837503 cites W1882746210 @default.
• W2611837503 cites W1929801250 @default.
• W2611837503 cites W1944804641 @default.
• W2611837503 cites W1963956528 @default.
• W2611837503 cites W1967290761 @default.
• W2611837503 cites W1976684529 @default.
• W2611837503 cites W1977137705 @default.
• W2611837503 cites W1984703718 @default.
• W2611837503 cites W1985932456 @default.
• W2611837503 cites W1986062308 @default.
• W2611837503 cites W1987729283 @default.
• W2611837503 cites W1994030039 @default.
• W2611837503 cites W1995188451 @default.
• W2611837503 cites W2000537629 @default.
• W2611837503 cites W2008255393 @default.
• W2611837503 cites W2009500827 @default.
• W2611837503 cites W2012403948 @default.
• W2611837503 cites W2020175229 @default.
• W2611837503 cites W2027276086 @default.
• W2611837503 cites W2027309603 @default.
• W2611837503 cites W2032863178 @default.
• W2611837503 cites W2035012256 @default.
• W2611837503 cites W2036722731 @default.
• W2611837503 cites W2039215781 @default.
• W2611837503 cites W2045949302 @default.
• W2611837503 cites W2047083143 @default.
• W2611837503 cites W2049112623 @default.
• W2611837503 cites W2049424828 @default.
• W2611837503 cites W2050138691 @default.
• W2611837503 cites W2057157065 @default.
• W2611837503 cites W2058079459 @default.
• W2611837503 cites W2059277649 @default.
• W2611837503 cites W2061478086 @default.
• W2611837503 cites W2064080583 @default.
• W2611837503 cites W2064423947 @default.
• W2611837503 cites W2068296821 @default.
• W2611837503 cites W2069288821 @default.
• W2611837503 cites W2070050178 @default.
• W2611837503 cites W2074643664 @default.
• W2611837503 cites W2079692423 @default.
• W2611837503 cites W2087952937 @default.
• W2611837503 cites W2096247886 @default.
• W2611837503 cites W2099864164 @default.
• W2611837503 cites W2101117089 @default.
• W2611837503 cites W2104007338 @default.
• W2611837503 cites W2106173827 @default.
• W2611837503 cites W2107018762 @default.
• W2611837503 cites W2109474508 @default.
• W2611837503 cites W2110905563 @default.
• W2611837503 cites W2112120380 @default.
• W2611837503 cites W2114104545 @default.
• W2611837503 cites W2117932726 @default.
• W2611837503 cites W2120287009 @default.
• W2611837503 cites W2129201575 @default.
• W2611837503 cites W2130597092 @default.
• W2611837503 cites W2130831665 @default.
• W2611837503 cites W2131271579 @default.
• W2611837503 cites W2131434727 @default.
• W2611837503 cites W2136514583 @default.
• W2611837503 cites W2138207763 @default.
• W2611837503 cites W2141707748 @default.
• W2611837503 cites W2147162709 @default.
• W2611837503 cites W2150583919 @default.
• W2611837503 cites W2153617971 @default.
• W2611837503 cites W2158217645 @default.
• W2611837503 cites W2159202946 @default.
• W2611837503 cites W2160358050 @default.
• W2611837503 cites W2160553059 @default.
• W2611837503 cites W2165002688 @default.
• W2611837503 cites W2166785367 @default.
• W2611837503 cites W2168777985 @default.
• W2611837503 cites W2169340948 @default.
• W2611837503 cites W2169674658 @default.
• W2611837503 cites W2186949423 @default.
• W2611837503 cites W2201382378 @default.
• W2611837503 cites W2209353711 @default.
• W2611837503 cites W2210080033 @default.
• W2611837503 cites W2252402984 @default.
• W2611837503 cites W2262705777 @default.
• W2611837503 cites W2305549058 @default.
• W2611837503 cites W2320470164 @default.
• W2611837503 cites W2345356016 @default.
• W2611837503 cites W2443212980 @default.
• W2611837503 cites W2474436782 @default.

• next