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- W2611994723 abstract "A combined E. coli cell metabolism-bioreactor system is described using an S-system model developed within the Biochemical System Theory framework. Such a model is able to represent the activities of the enzymes involved in the biotransformation process, the biotransformation compound concentrations and their transporter. In addition, the transporter is described as an ATP-dependent antiport of betaines and by considering the difference between the concentration of substrate (crotronobetaine) and product (L-carnitine) inside/outside (reactor bulk) the cell. The central metabolism, including glycerol assimilation through the glycolytic and the tricarboxylic acid pathway (TCA) and the synthesis of lactate, formate and acetate has also been modelled. Simulation results matched experiments run with the high-cell density reactor system." @default.
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- W2611994723 date "2004-03-01" @default.
- W2611994723 modified "2023-09-25" @default.
- W2611994723 title "Integrating the Microkinetics of the L-Carnitine and Central Metabolism in Escherichia coli with the Macrokinetics of a High-Cell Density Reactor" @default.
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- W2611994723 doi "https://doi.org/10.1016/s1474-6670(17)32574-0" @default.
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