Matches in SemOpenAlex for { <https://semopenalex.org/work/W2612049099> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W2612049099 abstract "Down’s syndrome is a complex genetic condition arising from trisomy of chromosome 21; it is characterised by alterations in behaviour and synaptic plasticity, leading to deficits in learning and memory. The Tc1 mouse is a transchromosomic mouse model of trisomy-21 which carries a freely segregating and almost complete human chromosome 21. The main aim of this thesis was to explore recognition memory processes in the Tc1 mouse model of trisomy-21.The initial goal was to provide insight into the learning and memory changes associated with triplication of genes on human chromosome 21 in mice. The Tc1 mouse had previously been shown to display a deficit in object recognition memory following a delay of 10-min, but not following a 24-h delay. This thesis aimed to confirmand extend these findings, by testing Tc1 mice on an array of novelty based recognition tasks. This thesis also aimed to explore some of the biological systems underpinning the pattern of learning and memory changes demonstrated by the Tc1 mouse. The expression of c- fos was used as a marker of neuronal activity, allowing for the assessment of regional activity, and in addition, the expression profile of the GluR1 subunit of the AMPA receptor and the GluK1 and GluK5 subunits of the Kainatereceptor were examined. Finally, this thesis investigated the impact of the administration of a novel AMPAkine, drug 9A, on the cognitive phenotype of the Tc1 mouse.The behavioural and biochemical analyses provided evidence that the Tc1 mouse model showed a selective deficit in short-term recognition memory while sparing longterm memory for the same type of information, and that a near complete copy of human chromosome 21 in Tc1 mice did not impair place recognition. In addition, c-fosexpression studies provided evidence for aberrant perirhinal cortex activity in response to familiarity. Further to this, there was a significant reduction in expression of the GluR1 AMPA receptor subunit in the hippocampus, and a significant reduction of theGluK5 kainate receptor subunit expression in the perirhinal cortex. Finally, this thesis provides some preliminary evidence that a novel positive allosteric modulator, drug 9a, had a positive cognitive enhancing effect in the Tc1 mouse." @default.
- W2612049099 created "2017-05-19" @default.
- W2612049099 creator A5015492935 @default.
- W2612049099 date "2016-01-01" @default.
- W2612049099 modified "2023-09-24" @default.
- W2612049099 title "Dissociating aberrant properties of recognition memory in the TC1 mouse model of Trisomy-21" @default.
- W2612049099 hasPublicationYear "2016" @default.
- W2612049099 type Work @default.
- W2612049099 sameAs 2612049099 @default.
- W2612049099 citedByCount "1" @default.
- W2612049099 countsByYear W26120490992019 @default.
- W2612049099 crossrefType "dissertation" @default.
- W2612049099 hasAuthorship W2612049099A5015492935 @default.
- W2612049099 hasConcept C104317684 @default.
- W2612049099 hasConcept C137555145 @default.
- W2612049099 hasConcept C15744967 @default.
- W2612049099 hasConcept C160268369 @default.
- W2612049099 hasConcept C169760540 @default.
- W2612049099 hasConcept C169900460 @default.
- W2612049099 hasConcept C170493617 @default.
- W2612049099 hasConcept C2776229224 @default.
- W2612049099 hasConcept C2781161787 @default.
- W2612049099 hasConcept C30481170 @default.
- W2612049099 hasConcept C54355233 @default.
- W2612049099 hasConcept C61174792 @default.
- W2612049099 hasConcept C86803240 @default.
- W2612049099 hasConcept C88576662 @default.
- W2612049099 hasConcept C90269970 @default.
- W2612049099 hasConcept C98229152 @default.
- W2612049099 hasConceptScore W2612049099C104317684 @default.
- W2612049099 hasConceptScore W2612049099C137555145 @default.
- W2612049099 hasConceptScore W2612049099C15744967 @default.
- W2612049099 hasConceptScore W2612049099C160268369 @default.
- W2612049099 hasConceptScore W2612049099C169760540 @default.
- W2612049099 hasConceptScore W2612049099C169900460 @default.
- W2612049099 hasConceptScore W2612049099C170493617 @default.
- W2612049099 hasConceptScore W2612049099C2776229224 @default.
- W2612049099 hasConceptScore W2612049099C2781161787 @default.
- W2612049099 hasConceptScore W2612049099C30481170 @default.
- W2612049099 hasConceptScore W2612049099C54355233 @default.
- W2612049099 hasConceptScore W2612049099C61174792 @default.
- W2612049099 hasConceptScore W2612049099C86803240 @default.
- W2612049099 hasConceptScore W2612049099C88576662 @default.
- W2612049099 hasConceptScore W2612049099C90269970 @default.
- W2612049099 hasConceptScore W2612049099C98229152 @default.
- W2612049099 hasLocation W26120490991 @default.
- W2612049099 hasOpenAccess W2612049099 @default.
- W2612049099 hasPrimaryLocation W26120490991 @default.
- W2612049099 hasRelatedWork W144253663 @default.
- W2612049099 hasRelatedWork W1893201598 @default.
- W2612049099 hasRelatedWork W1996293750 @default.
- W2612049099 hasRelatedWork W2026096441 @default.
- W2612049099 hasRelatedWork W2029118767 @default.
- W2612049099 hasRelatedWork W2074763603 @default.
- W2612049099 hasRelatedWork W2075069104 @default.
- W2612049099 hasRelatedWork W2103261384 @default.
- W2612049099 hasRelatedWork W2128514111 @default.
- W2612049099 hasRelatedWork W2149035338 @default.
- W2612049099 hasRelatedWork W2157353633 @default.
- W2612049099 hasRelatedWork W2196742277 @default.
- W2612049099 hasRelatedWork W2661234790 @default.
- W2612049099 hasRelatedWork W2735179394 @default.
- W2612049099 hasRelatedWork W2762137668 @default.
- W2612049099 hasRelatedWork W2783540423 @default.
- W2612049099 hasRelatedWork W2980803114 @default.
- W2612049099 hasRelatedWork W3007583009 @default.
- W2612049099 hasRelatedWork W3092596121 @default.
- W2612049099 hasRelatedWork W3135150931 @default.
- W2612049099 isParatext "false" @default.
- W2612049099 isRetracted "false" @default.
- W2612049099 magId "2612049099" @default.
- W2612049099 workType "dissertation" @default.