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- W2612080253 endingPage "53853" @default.
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- W2612080253 abstract "// Yizheng Yao 1 , Ying Ni 1 , Jiawen Zhang 1 , Hua Wang 1 and Shihe Shao 1 1 Institute of Laboratory Medicine, School of medicine, Jiangsu University, Zhenjiang, China Correspondence to: Hua Wang, email: wangjiahan1979@163.com Shihe Shao, email: shaoshihe2006@163.com Keywords: Notch signaling, gastric cancer, stemness, therapeutic targets Received: December 23, 2016 Accepted: April 17, 2017 Published: May 11, 2017 ABSTRACT Notch signaling, an evolutionarily conserved signaling cascade system, is involved in promoting the progression of different types of cancers. Within the past decades, the Notch signaling pathway has increasingly been shown to have a primary role in deciding the fate of cancer cells and cancer stem cells in the stomach. Most components of Notch signaling are strongly expressed at different levels in gastric carcinoma tissue samples and are associated with a considerable number of clinical parameters. Moreover, crosstalk signaling between the Notch pathway and the Wnt, Ras, and NF-κB pathways promotes the process of gastric carcinogenesis. Consequently, this increases proliferation and prevents apoptosis in gastric cancer cells, and it contributes to the induction of angiogenesis and accelerates the progression of the epithelial-to-mesenchymal transition. Although the Notch signaling pathway presents novel therapeutic targets for cancer therapeutic intervention, there is still a dearth of in-depth understanding of the molecular mechanisms of Notch signaling in gastric carcinoma. In this review, we summarize the landscape of the Notch signaling pathway and recent findings on Notch signaling in gastric cancer. Furthermore, advanced studies and clinical treatments targeting the Notch signaling pathway arediscussed." @default.
- W2612080253 created "2017-05-19" @default.
- W2612080253 creator A5007058151 @default.
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- W2612080253 creator A5088453711 @default.
- W2612080253 date "2017-05-11" @default.
- W2612080253 modified "2023-10-17" @default.
- W2612080253 title "The role of Notch signaling in gastric carcinoma: molecular pathogenesis and novel therapeutic targets" @default.
- W2612080253 cites W1489033175 @default.
- W2612080253 cites W1501944221 @default.
- W2612080253 cites W1506167971 @default.
- W2612080253 cites W1524205162 @default.
- W2612080253 cites W1586879291 @default.
- W2612080253 cites W1642299696 @default.
- W2612080253 cites W1770833348 @default.
- W2612080253 cites W1832569112 @default.
- W2612080253 cites W188237391 @default.
- W2612080253 cites W1904460196 @default.
- W2612080253 cites W1942403634 @default.
- W2612080253 cites W1955873587 @default.
- W2612080253 cites W1966057345 @default.
- W2612080253 cites W1967152980 @default.
- W2612080253 cites W1976109713 @default.
- W2612080253 cites W1981517279 @default.
- W2612080253 cites W1981989535 @default.
- W2612080253 cites W1984295575 @default.
- W2612080253 cites W1984979304 @default.
- W2612080253 cites W1987662957 @default.
- W2612080253 cites W1991697476 @default.
- W2612080253 cites W1991797784 @default.
- W2612080253 cites W1993067885 @default.
- W2612080253 cites W1997801717 @default.
- W2612080253 cites W1998214135 @default.
- W2612080253 cites W1999636129 @default.
- W2612080253 cites W1999672487 @default.
- W2612080253 cites W2000179703 @default.
- W2612080253 cites W2001286107 @default.
- W2612080253 cites W2007921174 @default.
- W2612080253 cites W2009441433 @default.
- W2612080253 cites W2009879133 @default.
- W2612080253 cites W2010204335 @default.
- W2612080253 cites W2013540020 @default.
- W2612080253 cites W2014253046 @default.
- W2612080253 cites W2015185372 @default.
- W2612080253 cites W2016112105 @default.
- W2612080253 cites W2018537679 @default.
- W2612080253 cites W2019007505 @default.
- W2612080253 cites W2019484386 @default.
- W2612080253 cites W2019688531 @default.
- W2612080253 cites W2019769268 @default.
- W2612080253 cites W2024490989 @default.
- W2612080253 cites W2030056609 @default.
- W2612080253 cites W2034953483 @default.
- W2612080253 cites W2040775078 @default.
- W2612080253 cites W2040827891 @default.
- W2612080253 cites W2042082068 @default.
- W2612080253 cites W2052334769 @default.
- W2612080253 cites W2053363358 @default.
- W2612080253 cites W2054001958 @default.
- W2612080253 cites W2054483302 @default.
- W2612080253 cites W2057421005 @default.
- W2612080253 cites W2057496598 @default.
- W2612080253 cites W2057575001 @default.
- W2612080253 cites W2057881265 @default.
- W2612080253 cites W2058062440 @default.
- W2612080253 cites W2058734213 @default.
- W2612080253 cites W2061194564 @default.
- W2612080253 cites W2061738087 @default.
- W2612080253 cites W2061996746 @default.
- W2612080253 cites W2062150443 @default.
- W2612080253 cites W2065159578 @default.
- W2612080253 cites W2069378448 @default.
- W2612080253 cites W2077220677 @default.
- W2612080253 cites W2082195162 @default.
- W2612080253 cites W2083425643 @default.
- W2612080253 cites W2084614897 @default.
- W2612080253 cites W2086059239 @default.
- W2612080253 cites W2091022798 @default.
- W2612080253 cites W2091341060 @default.
- W2612080253 cites W2091753918 @default.
- W2612080253 cites W2093384214 @default.
- W2612080253 cites W2095397411 @default.
- W2612080253 cites W2096237102 @default.
- W2612080253 cites W2096504451 @default.
- W2612080253 cites W2097598334 @default.
- W2612080253 cites W2097739264 @default.
- W2612080253 cites W2098041761 @default.
- W2612080253 cites W2098456531 @default.
- W2612080253 cites W2098503611 @default.
- W2612080253 cites W2098640128 @default.
- W2612080253 cites W2099735892 @default.
- W2612080253 cites W2101496994 @default.
- W2612080253 cites W2102679813 @default.
- W2612080253 cites W2103694596 @default.
- W2612080253 cites W2104593525 @default.
- W2612080253 cites W2105844486 @default.