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• W2612363326 abstract "The paper describes a highly space-resolved characterization of the surface mechanical properties of the posterior human corneal layer (Descemet's membrane). This has been accomplished with Atomic Force Microscopy (AFM) nano-indentation by using a probe with a sharp tip geometry. Results indicate that the contact with this biological tissue in liquid occurs with no (or very low) adhesion. More importantly, under the same operating conditions, a broad distribution of penetration depth can be measured on different x-y positions of the tissue surface, indicating a high inhomogeneity of surface stiffness, not yet clearly reported in the literature. An important contribution to such inhomogeneity should be ascribed to the discontinuous nature of the collagen/proteoglycans fibers matrix tissue, as can be imaged by AFM when the tissue is semi-dry. Using classical contact mechanics calculations adapted to the specific geometry of the tetrahedral tip it has been found that the elastic modulus E of the material in the very proximity of the surface ranges from 0.23 to 2.6 kPa." @default.
• W2612363326 created "2017-05-19" @default.
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• W2612363326 date "2017-10-01" @default.
• W2612363326 modified "2023-10-16" @default.
• W2612363326 title "Sensing inhomogeneous mechanical properties of human corneal Descemet's membrane with AFM nano-indentation" @default.
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• W2612363326 doi "https://doi.org/10.1016/j.jmbbm.2017.05.019" @default.
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