Matches in SemOpenAlex for { <https://semopenalex.org/work/W2612371147> ?p ?o ?g. }
- W2612371147 endingPage "469" @default.
- W2612371147 startingPage "454" @default.
- W2612371147 abstract "Targeting upstream phosphatidylinositol-3-kinases (PI3Ks) in the PI3K/Akt/mTOR pathway appears to be a promising therapy in solid cancers; however, first early clinical trials with PI3K inhibitors in monotherapy have been disappointing. A massive array of preclinical and clinical trials are currently evaluating combinations of PI3K inhibitors in targeted therapies. These combinations include co-treatments with drugs directed against other intra-/extracellular signaling molecules, nuclear hormone receptors, DNA damage repair enzymes, and immune modulators. We review the literature and pinpoint mechanisms of action in different genomic and organ contexts. Combinatorial approaches are potentially superior to monotherapies and should become alternative clinical strategies to treat cancer patients." @default.
- W2612371147 created "2017-05-19" @default.
- W2612371147 creator A5010990336 @default.
- W2612371147 creator A5026016354 @default.
- W2612371147 creator A5031663089 @default.
- W2612371147 date "2017-06-01" @default.
- W2612371147 modified "2023-10-14" @default.
- W2612371147 title "Targeting PI3K Signaling in Combination Cancer Therapy" @default.
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