FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2612476887> ?p ?o ?g. }

• W2612476887 endingPage "65076" @default.
• W2612476887 startingPage "65064" @default.
• W2612476887 abstract "// Ji-Ye Kim 1, 2 , Hyang Sook Jeong 2 , Taek Chung 2 , Moonsik Kim 2 , Ji Hee Lee 2 , Woo Hee Jung 2 and Ja Seung Koo 2 1 Department of Pathology and Translational Genomics, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Republic of Korea 2 Department of Pathology, Yonsei University College of Medicine, Severance Hospital, Seoul, Republic of Korea Correspondence to: Ja Seung Koo, email: kjs1976@yuhs.ac Keywords: PHH3, invasive breast cancer, proliferation, reproducibility, prognostic value Received: February 26, 2016      Accepted: April 25, 2017      Published: May 10, 2017 ABSTRACT Background: Established measurements of proliferation in breast cancer are Ki67 and mitotic-activity-index (MAI), with problems in reproducibility and prognostic accuracy. Phosphohistone H3 (PHH3), a relatively novel IHC marker is specific for mitosis with good reproducibility. We hypothesized that PHH3 would be more reproducible and better represent proliferation than Ki67. Results: PHH3 identified easily-missed mitosis by MAI, as demonstrated by upgrading M grade at diagnosis ( n = 29/218, evenly distributed). PHH3 accurately found hot-spots, supported by mitotic count agreement between low-power and 10HPFs (R 2 = 0.999; P = 0.001). PHH3 was more reproducible than Ki67, measured by five-rater inter-class correlation coefficient (0.904 > 0.712; P = 0.008). Finally, despite a relatively short follow-up (median 46 months; 7 recurrences) PHH3 was the only variable correlated with disease-free survival ( P = 0.043), while all other conventional clinicopathologic variables, including Ki67 ( P = 0.356), did not. Materials and Methods: We compared Ki67 and PHH3 for 218 breast cancer surgical cases diagnosed from 2012 to 2013 at Severance hospital. The most representative invasive breast cancer surgical slides were immunohistochemically stained for Ki67 and PHH3. Conclusions: Poor reproducibility and inadequate representation of proliferation of Ki67 and MAI may be improved by PHH3, allowing better accuracy in breast cancer diagnostics." @default.
• W2612476887 created "2017-05-19" @default.
• W2612476887 creator A5016965481 @default.
• W2612476887 creator A5021381253 @default.
• W2612476887 creator A5029443992 @default.
• W2612476887 creator A5036350381 @default.
• W2612476887 creator A5040856605 @default.
• W2612476887 creator A5070136309 @default.
• W2612476887 creator A5070538830 @default.
• W2612476887 date "2017-05-10" @default.
• W2612476887 modified "2023-10-15" @default.
• W2612476887 title "The value of phosphohistone H3 as a proliferation marker for evaluating invasive breast cancers: A comparative study with Ki67" @default.
• W2612476887 cites W1500469991 @default.
• W2612476887 cites W1685498172 @default.
• W2612476887 cites W1964153122 @default.
• W2612476887 cites W1979410391 @default.
• W2612476887 cites W1991747030 @default.
• W2612476887 cites W2002053831 @default.
• W2612476887 cites W2007918562 @default.
• W2612476887 cites W2010871781 @default.
• W2612476887 cites W2038024232 @default.
• W2612476887 cites W2040029747 @default.
• W2612476887 cites W2043620199 @default.
• W2612476887 cites W2044702943 @default.
• W2612476887 cites W2049578627 @default.
• W2612476887 cites W2053226329 @default.
• W2612476887 cites W2055239896 @default.
• W2612476887 cites W2072998066 @default.
• W2612476887 cites W2074820139 @default.
• W2612476887 cites W2082172177 @default.
• W2612476887 cites W2100800745 @default.
• W2612476887 cites W2101645192 @default.
• W2612476887 cites W2102163800 @default.
• W2612476887 cites W2102891340 @default.
• W2612476887 cites W2116374810 @default.
• W2612476887 cites W2120343162 @default.
• W2612476887 cites W2127057139 @default.
• W2612476887 cites W2129121565 @default.
• W2612476887 cites W2130900820 @default.
• W2612476887 cites W2131754688 @default.
• W2612476887 cites W2132893003 @default.
• W2612476887 cites W2134520863 @default.
• W2612476887 cites W2137853125 @default.
• W2612476887 cites W2140861294 @default.
• W2612476887 cites W2144535237 @default.
• W2612476887 cites W2150134401 @default.
• W2612476887 cites W2151134970 @default.
• W2612476887 cites W2168860104 @default.
• W2612476887 cites W2169160999 @default.
• W2612476887 cites W2312895542 @default.
• W2612476887 doi "https://doi.org/10.18632/oncotarget.17775" @default.
• W2612476887 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5630312" @default.
• W2612476887 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29029412" @default.
• W2612476887 hasPublicationYear "2017" @default.
• W2612476887 type Work @default.
• W2612476887 sameAs 2612476887 @default.
• W2612476887 citedByCount "69" @default.
• W2612476887 countsByYear W26124768872018 @default.
• W2612476887 countsByYear W26124768872019 @default.
• W2612476887 countsByYear W26124768872020 @default.
• W2612476887 countsByYear W26124768872021 @default.
• W2612476887 countsByYear W26124768872022 @default.
• W2612476887 countsByYear W26124768872023 @default.
• W2612476887 crossrefType "journal-article" @default.
• W2612476887 hasAuthorship W2612476887A5016965481 @default.
• W2612476887 hasAuthorship W2612476887A5021381253 @default.
• W2612476887 hasAuthorship W2612476887A5029443992 @default.
• W2612476887 hasAuthorship W2612476887A5036350381 @default.
• W2612476887 hasAuthorship W2612476887A5040856605 @default.
• W2612476887 hasAuthorship W2612476887A5070136309 @default.
• W2612476887 hasAuthorship W2612476887A5070538830 @default.
• W2612476887 hasBestOaLocation W26124768871 @default.
• W2612476887 hasConcept C121608353 @default.
• W2612476887 hasConcept C126322002 @default.
• W2612476887 hasConcept C142724271 @default.
• W2612476887 hasConcept C143998085 @default.
• W2612476887 hasConcept C530470458 @default.
• W2612476887 hasConcept C66640590 @default.
• W2612476887 hasConcept C71924100 @default.
• W2612476887 hasConcept C86803240 @default.
• W2612476887 hasConcept C93304396 @default.
• W2612476887 hasConcept C95444343 @default.
• W2612476887 hasConceptScore W2612476887C121608353 @default.
• W2612476887 hasConceptScore W2612476887C126322002 @default.
• W2612476887 hasConceptScore W2612476887C142724271 @default.
• W2612476887 hasConceptScore W2612476887C143998085 @default.
• W2612476887 hasConceptScore W2612476887C530470458 @default.
• W2612476887 hasConceptScore W2612476887C66640590 @default.
• W2612476887 hasConceptScore W2612476887C71924100 @default.
• W2612476887 hasConceptScore W2612476887C86803240 @default.
• W2612476887 hasConceptScore W2612476887C93304396 @default.
• W2612476887 hasConceptScore W2612476887C95444343 @default.
• W2612476887 hasIssue "39" @default.
• W2612476887 hasLocation W26124768871 @default.
• W2612476887 hasLocation W26124768872 @default.
• W2612476887 hasLocation W26124768873 @default.
• W2612476887 hasLocation W26124768874 @default.
• W2612476887 hasLocation W26124768875 @default.

• next