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• W2612479906 abstract "Abstract Background: The molecular mechanisms involved in tumorigenesis of lung cancer remain to be further elucidated. MicroRNA (miRNA) is a class of non-coding RNAs associated with carcinogenesis. The present study aims to investigate the role of miRNA-101 (miR-101) in lung cancer. Methods: MiR-101 was measured in human non-small cell lung cancer (NSCLC) tissues compared with the matched adjacent tissues. MiR-101 was transfected into NSCLC A549 cells. Bioinformatics predictions revealed a potential binding site of miR-101 on the 3′UTR of C-Fos, which was further confirmed by the luciferase assay. Western blot analysis and knockdown method were used to detect the expression and function of C-Fos Results: The expression of miR-101 was downregulated in NSCLC. Overexpression of miR-101 suppressed cell proliferation of NSCLC A549 cells, and induced cell apoptosis. C-Fos was downregulated by miR-101 at the protein level. In addition, knockdown of C-Fos induced similar effects as overexpression of miR-101 in NSCLC cells. Conclusion: These findings indicate that miR-101 regulate NSCLC cells growth through targeting C-Fos. Thus, strategies on C-Fos and/or miR-101 may be a potential molecular therapy for NSCLC." @default.
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• W2612479906 date "2017-01-01" @default.
• W2612479906 modified "2023-09-30" @default.
• W2612479906 title "MicroRNA-101 downregulation increases C-Fos expression and contributes to the pathogenesis of non-small cell lung cancer" @default.
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• W2612479906 doi "https://doi.org/10.1515/tjb-2016-0133" @default.
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