Matches in SemOpenAlex for { <https://semopenalex.org/work/W2612499046> ?p ?o ?g. }
- W2612499046 abstract "Mechanical pain serves as a base clinical symptom for many of the world's most debilitating syndromes. Ion channels expressed by peripheral sensory neurons largely contribute to mechanical hypersensitivity. Transient Receptor Potential A 1 (TRPA1) is a ligand-gated ion channel that contributes to inflammatory mechanical hypersensitivity, yet little is known as to the post-translational mechanism behind its somatosensitization. Here, we utilize biochemical, electrophysiological, and behavioral measures to demonstrate that metabotropic glutamate receptor-induced sensitization of TRPA1 nociceptors stimulates targeted modification of the receptor. Type 1 mGluR5 activation increases TRPA1 receptor agonist sensitivity in an AKA-dependent manner. As a scaffolding protein for Protein Kinases A and C (PKA and PKC, respectively), AKAP facilitates phosphorylation and sensitization of TRPA1 in ex vivo sensory neuronal preparations. Furthermore, hyperalgesic priming of mechanical hypersensitivity requires both TRPA1 and AKAP. Collectively, these results identify a novel AKAP-mediated biochemical mechanism that increases TRPA1 sensitivity in peripheral sensory neurons, and likely contributes to persistent mechanical hypersensitivity." @default.
- W2612499046 created "2017-05-19" @default.
- W2612499046 creator A5000981401 @default.
- W2612499046 creator A5025723644 @default.
- W2612499046 creator A5033043600 @default.
- W2612499046 creator A5042090795 @default.
- W2612499046 creator A5048204247 @default.
- W2612499046 creator A5067715356 @default.
- W2612499046 creator A5068132316 @default.
- W2612499046 creator A5077086042 @default.
- W2612499046 date "2017-05-12" @default.
- W2612499046 modified "2023-10-10" @default.
- W2612499046 title "A-Kinase Anchoring Protein 79/150 Scaffolds Transient Receptor Potential A 1 Phosphorylation and Sensitization by Metabotropic Glutamate Receptor Activation" @default.
- W2612499046 cites W1505976679 @default.
- W2612499046 cites W1570505030 @default.
- W2612499046 cites W1600528148 @default.
- W2612499046 cites W1709837271 @default.
- W2612499046 cites W1775400584 @default.
- W2612499046 cites W1819370145 @default.
- W2612499046 cites W1883732752 @default.
- W2612499046 cites W1893612865 @default.
- W2612499046 cites W1917163647 @default.
- W2612499046 cites W1925074995 @default.
- W2612499046 cites W1942930266 @default.
- W2612499046 cites W1958770111 @default.
- W2612499046 cites W1969902527 @default.
- W2612499046 cites W1974620224 @default.
- W2612499046 cites W1976307613 @default.
- W2612499046 cites W1982908158 @default.
- W2612499046 cites W1984033377 @default.
- W2612499046 cites W1984533345 @default.
- W2612499046 cites W1993208651 @default.
- W2612499046 cites W1997398185 @default.
- W2612499046 cites W1999383552 @default.
- W2612499046 cites W1999720993 @default.
- W2612499046 cites W2000104695 @default.
- W2612499046 cites W2006706073 @default.
- W2612499046 cites W2009967312 @default.
- W2612499046 cites W2017421910 @default.
- W2612499046 cites W2018543284 @default.
- W2612499046 cites W2020833052 @default.
- W2612499046 cites W2026986930 @default.
- W2612499046 cites W2028450129 @default.
- W2612499046 cites W2029608563 @default.
- W2612499046 cites W2029922907 @default.
- W2612499046 cites W2030049281 @default.
- W2612499046 cites W2035257142 @default.
- W2612499046 cites W2038655108 @default.
- W2612499046 cites W2042488869 @default.
- W2612499046 cites W2045183511 @default.
- W2612499046 cites W2046687620 @default.
- W2612499046 cites W2049100687 @default.
- W2612499046 cites W2060053691 @default.
- W2612499046 cites W2062978707 @default.
- W2612499046 cites W2064374911 @default.
- W2612499046 cites W2066905281 @default.
- W2612499046 cites W2067859370 @default.
- W2612499046 cites W2069183005 @default.
- W2612499046 cites W2069865837 @default.
- W2612499046 cites W2073197172 @default.
- W2612499046 cites W2074027763 @default.
- W2612499046 cites W2080991292 @default.
- W2612499046 cites W2081056347 @default.
- W2612499046 cites W2082637975 @default.
- W2612499046 cites W2088450431 @default.
- W2612499046 cites W2090389679 @default.
- W2612499046 cites W2096445692 @default.
- W2612499046 cites W2102129421 @default.
- W2612499046 cites W2104244040 @default.
- W2612499046 cites W2109644936 @default.
- W2612499046 cites W2109879418 @default.
- W2612499046 cites W2113758041 @default.
- W2612499046 cites W2118612841 @default.
- W2612499046 cites W2119832782 @default.
- W2612499046 cites W2124503501 @default.
- W2612499046 cites W2128635872 @default.
- W2612499046 cites W2130277691 @default.
- W2612499046 cites W2132676412 @default.
- W2612499046 cites W2144014198 @default.
- W2612499046 cites W2156733405 @default.
- W2612499046 cites W2156887209 @default.
- W2612499046 cites W2164073806 @default.
- W2612499046 cites W2165179388 @default.
- W2612499046 cites W2166086438 @default.
- W2612499046 cites W2170387852 @default.
- W2612499046 cites W2171223432 @default.
- W2612499046 cites W2173428397 @default.
- W2612499046 cites W2230584977 @default.
- W2612499046 cites W2290776876 @default.
- W2612499046 cites W2412663073 @default.
- W2612499046 cites W2420872844 @default.
- W2612499046 cites W4249390745 @default.
- W2612499046 cites W4293247451 @default.
- W2612499046 cites W4300258638 @default.
- W2612499046 doi "https://doi.org/10.1038/s41598-017-01999-4" @default.
- W2612499046 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5431798" @default.
- W2612499046 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28500286" @default.
- W2612499046 hasPublicationYear "2017" @default.
- W2612499046 type Work @default.
- W2612499046 sameAs 2612499046 @default.