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• W2612512857 abstract "Rhabdomyolysis is defined as a clinical and laboratory syndrome as a consequence of skeletal muscle injury resulting in the release of muscular cell constituents, predominantly myoglobin into the extracellular fluid and the circulation. There is a varied spectrum of severity of rhabdomyolysis ranging from a subclinical increase in creatine kinase (CK) levels to interstitial and muscle cell oedema, and pigment-induced acute kidney injury (AKI). Causes of rhabdomyolysis can be divided into traumatic, including crush injuries, long-term confinement to the same position and strenuous exercise, and non-traumatic, such as infections, drugs, myopathies and hyperthermia. University Hospital Geelong is the largest regional tertiary hospital in Victoria, Australia. We reviewed ICD-10-AM coding data for diagnoses of rhabdomyolysis over a 10-year period at our institution. Utilising relevant ICD-10 codes, a retrospective review of medical records from May 2006 to May 2016 of patients coded with a diagnosis of rhabdomyolysis was undertaken. An episode of rhabdomyolysis was defined as acute elevation of serum CK value greater than five times the upper limit of normal (>1000 U/L). Data extracted included: patient demographics, aetiologies of rhabdomyolysis, laboratory results including serum CK and renal function, use of renal replacement therapy and death. 631 patients were identified. Of these, 248 patients were excluded based on a diagnosis of myocardial infarction, serum CK levels which did not meet the criteria for rhabdomyolysis, and duplicated or inadequate data from medical records. 383 patients met the definition of rhabdomyolysis and were included in the analysis. 220 were males and 163 were females, of median age 71 years. The leading causes of rhabdomyolysis were prolonged immobility (71%), infection (6%), decreased blood supply (5%) and physical exertion (4.2%). AKI was present in 229 patients (59.8%) on presentation and 38 patients (9.9%) required renal replacement therapy. The mean peak serum creatinine was 212 μmol/L. Death resulted in 7.6% of patients during their admission. In this 10-year review of cases of rhabdomyolysis at a regional tertiary care centre, we identified 383 cases of rhabdomyolysis. Rhabdomyolysis was more common among males and the most common cause was prolonged immobility. 9.9% of patients required renal replacement therapy and 7.6% died." @default.
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• W2612512857 date "2017-05-01" @default.
• W2612512857 modified "2023-09-27" @default.
• W2612512857 title "Rhabdomyolysis: review of cases over a decade at a regional teaching hospital" @default.
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• W2612512857 doi "https://doi.org/10.1111/imj.5_13461" @default.
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