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- W2612567924 abstract "The past decade has been proclaimed as a hugely successful era of gene discovery through the high yields of many genome-wide association studies (GWAS). However, much of the perceived benefit of such discoveries lies in the promise that the identification of genes that influence disease would directly translate into the identification of potential therapeutic targets (1-4), but this has yet to be realised at a level reflecting expectation. One reason for this, we suggest, is that GWAS to date have generally not focused on phenotypes that directly relate to the progression of disease, and thus speak to disease treatment." @default.
- W2612567924 created "2017-05-19" @default.
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- W2612567924 date "2017-05-08" @default.
- W2612567924 modified "2023-09-27" @default.
- W2612567924 title "Genetic epidemiology and Mendelian randomization for informing disease therapeutics: conceptual and methodological challenges" @default.
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- W2612567924 doi "https://doi.org/10.1101/126599" @default.
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