FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2612569520> ?p ?o ?g. }

• W2612569520 abstract "Background: Atopic dermatitis (AD) is characterized by skin infiltration with eosinophils and lymphocytes and expression of Th2 cytokines in acute skin lesions. The skin of patients with AD is frequently colonized with enterotoxin-secreting strains of Staphylococcus aureus. Staphylococcal enterotoxins have been implicated in the exacerbations of the inflammatory skin lesions in patients with AD. Objective: We sought to determine whether epicutaneous (EC) sensitization of mice with staphylococcal enterotoxin B (SEB) results in allergic skin inflammation. Methods: BALB/c mice were EC-sensitized with SEB. Their skin was examined for allergic inflammation and cytokine expression, and their splenocytes were examined for cytokine secretion in response to SEB. Results: EC sensitization with SEB elicited a local, cutaneous, inflammatory response characterized by dermal infiltration with eosinophils and mononuclear cells and increased mRNA expression of the Th2 cytokine IL-4 but not of the Th1 cytokine IFN-γ. EC-sensitized mice mounted a systemic Th2 response to SEB evidenced by elevated total and SEB-specific IgG1 and IgE. Although EC sensitization with SEB resulted in selective depletion of SEB-specific T-cell receptor Vβ8+ cells from the spleen and sensitized skin, splenocytes from SEB-sensitized mice secreted relatively more IL-4 and less IFN-γ than did saline-sensitized controls, consistent with Th 2 skewing of the systemic immune response to the superantigen. Conclusion: These results suggest that EC exposure to superantigens skews the immune response toward Th2 cells, leading to allergic skin inflammation and increased IgE synthesis that are characteristic of AD. (J Allergy Clin Immunol 2003;112:981-7.)" @default.
• W2612569520 created "2017-05-19" @default.
• W2612569520 creator A5006817794 @default.
• W2612569520 creator A5008959408 @default.
• W2612569520 creator A5022624850 @default.
• W2612569520 creator A5036274299 @default.
• W2612569520 creator A5040703340 @default.
• W2612569520 creator A5048379219 @default.
• W2612569520 creator A5082623488 @default.
• W2612569520 date "2003-01-01" @default.
• W2612569520 modified "2023-09-23" @default.
• W2612569520 title "Dermatologic and ocular diseases Epicutaneous sensitization with superantigen induces allergic skin inflammation" @default.
• W2612569520 cites W1601996991 @default.
• W2612569520 cites W1606747000 @default.
• W2612569520 cites W1666173184 @default.
• W2612569520 cites W1761832237 @default.
• W2612569520 cites W1971587265 @default.
• W2612569520 cites W1974682549 @default.
• W2612569520 cites W1977441232 @default.
• W2612569520 cites W1978974605 @default.
• W2612569520 cites W1985669456 @default.
• W2612569520 cites W1993579741 @default.
• W2612569520 cites W1994366381 @default.
• W2612569520 cites W1994515826 @default.
• W2612569520 cites W2003260060 @default.
• W2612569520 cites W2011824330 @default.
• W2612569520 cites W2031087744 @default.
• W2612569520 cites W2039627333 @default.
• W2612569520 cites W2040512118 @default.
• W2612569520 cites W2052567569 @default.
• W2612569520 cites W2052828401 @default.
• W2612569520 cites W2061496382 @default.
• W2612569520 cites W2072910716 @default.
• W2612569520 cites W2079296266 @default.
• W2612569520 cites W2084851155 @default.
• W2612569520 cites W2091552406 @default.
• W2612569520 cites W2096279219 @default.
• W2612569520 cites W2099791606 @default.
• W2612569520 cites W2120881176 @default.
• W2612569520 cites W2155182018 @default.
• W2612569520 cites W2411917933 @default.
• W2612569520 cites W2419496120 @default.
• W2612569520 hasPublicationYear "2003" @default.
• W2612569520 type Work @default.
• W2612569520 sameAs 2612569520 @default.
• W2612569520 citedByCount "0" @default.
• W2612569520 crossrefType "journal-article" @default.
• W2612569520 hasAuthorship W2612569520A5006817794 @default.
• W2612569520 hasAuthorship W2612569520A5008959408 @default.
• W2612569520 hasAuthorship W2612569520A5022624850 @default.
• W2612569520 hasAuthorship W2612569520A5036274299 @default.
• W2612569520 hasAuthorship W2612569520A5040703340 @default.
• W2612569520 hasAuthorship W2612569520A5048379219 @default.
• W2612569520 hasAuthorship W2612569520A5082623488 @default.
• W2612569520 hasConcept C141105273 @default.
• W2612569520 hasConcept C159654299 @default.
• W2612569520 hasConcept C203014093 @default.
• W2612569520 hasConcept C207480886 @default.
• W2612569520 hasConcept C2776090121 @default.
• W2612569520 hasConcept C2776217527 @default.
• W2612569520 hasConcept C2776914184 @default.
• W2612569520 hasConcept C2778329239 @default.
• W2612569520 hasConcept C2778690821 @default.
• W2612569520 hasConcept C2779675166 @default.
• W2612569520 hasConcept C36333154 @default.
• W2612569520 hasConcept C71924100 @default.
• W2612569520 hasConcept C8891405 @default.
• W2612569520 hasConceptScore W2612569520C141105273 @default.
• W2612569520 hasConceptScore W2612569520C159654299 @default.
• W2612569520 hasConceptScore W2612569520C203014093 @default.
• W2612569520 hasConceptScore W2612569520C207480886 @default.
• W2612569520 hasConceptScore W2612569520C2776090121 @default.
• W2612569520 hasConceptScore W2612569520C2776217527 @default.
• W2612569520 hasConceptScore W2612569520C2776914184 @default.
• W2612569520 hasConceptScore W2612569520C2778329239 @default.
• W2612569520 hasConceptScore W2612569520C2778690821 @default.
• W2612569520 hasConceptScore W2612569520C2779675166 @default.
• W2612569520 hasConceptScore W2612569520C36333154 @default.
• W2612569520 hasConceptScore W2612569520C71924100 @default.
• W2612569520 hasConceptScore W2612569520C8891405 @default.
• W2612569520 hasLocation W26125695201 @default.
• W2612569520 hasOpenAccess W2612569520 @default.
• W2612569520 hasPrimaryLocation W26125695201 @default.
• W2612569520 hasRelatedWork W1598450209 @default.
• W2612569520 hasRelatedWork W1929446732 @default.
• W2612569520 hasRelatedWork W1972919078 @default.
• W2612569520 hasRelatedWork W1985977440 @default.
• W2612569520 hasRelatedWork W1987812488 @default.
• W2612569520 hasRelatedWork W1999020075 @default.
• W2612569520 hasRelatedWork W2011703531 @default.
• W2612569520 hasRelatedWork W2024979136 @default.
• W2612569520 hasRelatedWork W2034841758 @default.
• W2612569520 hasRelatedWork W2051194064 @default.
• W2612569520 hasRelatedWork W2051780114 @default.
• W2612569520 hasRelatedWork W2054761517 @default.
• W2612569520 hasRelatedWork W2061496382 @default.
• W2612569520 hasRelatedWork W2090179022 @default.
• W2612569520 hasRelatedWork W2091639781 @default.
• W2612569520 hasRelatedWork W2301691565 @default.
• W2612569520 hasRelatedWork W2604751010 @default.

• next