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- W2612587600 abstract "Osteopontin (OPN) is a secreted phosphoglycoprotein, and is a transcriptional target of aberrant Wnt signaling. OPN is upregulated in human colon cancers, and is suggested to enhance cancer progression. In this study, the effect of deficiency of OPN on intestinal tumor development in Apc-deficient Min mice was investigated. At 16 weeks of age, the number of small intestinal polyps in Min/OPN(+/−) and Min/OPN(−/−) mice was lower than that of Min/OPN(+/+) mice. Colorectal tumor incidences and multiplicities in Min/OPN(+/−) and Min/OPN(−/−) mice were significantly lower than those in Min/OPN(+/+) mice, being 48% and 0.6 ± 0.8, 50% and 0.8 ± 0.9 vs. 80% and 1.6 ± 1.7, respectively. OPN expression in colorectal tumors was strongly upregulated in Min/OPN(+/+) compared to adjacent non-tumor parts, but was decreased in Min/OPN(+/−) and not detected in Min/OPN(−/−). Targets of OPN, matrix metalloproteinases (MMPs)-3, -9, and -13 were lowered by OPN deficiency. Macrophage marker F4/80 in colorectal tumors was also lowered by OPN deficiency. MMP-9 expression was observed in tumor cells and tumor-infiltrating neutrophils. These results indicate that induction of OPN by aberrant Wnt signaling could enhance colorectal tumor development in part by upregulation of MMP-3, -9, and -13 and infiltration of macrophage and neutrophils. Suppression of OPN expression could contribute to tumor prevention, but complete deficiency of OPN may cause some adverse effects." @default.
- W2612587600 created "2017-05-19" @default.
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- W2612587600 date "2017-05-14" @default.
- W2612587600 modified "2023-10-01" @default.
- W2612587600 title "Osteopontin Deficiency Suppresses Intestinal Tumor Development in Apc-Deficient Min Mice" @default.
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- W2612587600 doi "https://doi.org/10.3390/ijms18051058" @default.
- W2612587600 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5454970" @default.
- W2612587600 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28505114" @default.
- W2612587600 hasPublicationYear "2017" @default.
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