FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2612650019> ?p ?o ?g. }

• W2612650019 endingPage "e0177452" @default.
• W2612650019 startingPage "e0177452" @default.
• W2612650019 abstract "Puerto Rico has one of the highest rates of HIV/AIDS seen for any US state or territory, and antiretroviral therapy has been a mainstay of efforts to mitigate the HIV/AIDS public health burden on the island. We studied the evolutionary dynamics of HIV-1 mutation and antiretroviral drug resistance in Puerto Rico by monitoring the population frequency of resistance-associated mutations from 2002 to 2011. Whole blood samples from 4,475 patients were analyzed using the TRUGENE HIV-1 Genotyping Kit and OpenGene DNA Sequencing System in the Immunoretrovirus Research Laboratory at Universidad Central del Caribe. Results show that 64.0% of female and 62.9% of male patients had HIV-1 mutations that confer resistance to at least one antiretroviral medication. L63P and M184V were the dominant mutations observed for the protease (PRO) and reverse transcriptase (RT) encoding genes, respectively. Specific resistance mutations, along with their associated drug resistance profiles, can be seen to form temporal clusters that reveal a steadily changing landscape of resistance trends over time. Both women and men showed resistance mutations for an average of 4.8 drugs over the 10-year period, further underscoring the strong selective pressure exerted by antiretrovirals along with the rapid adaptive response of HIV. Nevertheless, both female and male patients showed a precipitous decrease for overall drug resistance, and for PRO mutations in particular, over the entire course of the study, with the most rapid decrease in frequency seen after 2006. The reduced HIV-1 mutation and drug resistance trends that we observed are consistent with previous reports from multi-year studies conducted around the world. Reduced resistance can be attributed to the use of more efficacious antiretroviral drug therapy, including the introduction of multi-drug combination therapies, which limited the ability of the virus to mount rapid adaptive responses to antiretroviral selection pressure." @default.
• W2612650019 created "2017-05-19" @default.
• W2612650019 creator A5031916073 @default.
• W2612650019 creator A5056585290 @default.
• W2612650019 creator A5062048502 @default.
• W2612650019 creator A5066604159 @default.
• W2612650019 creator A5070187831 @default.
• W2612650019 creator A5070688663 @default.
• W2612650019 creator A5077617304 @default.
• W2612650019 date "2017-05-11" @default.
• W2612650019 modified "2023-10-13" @default.
• W2612650019 title "A decade of viral mutations and associated drug resistance in a population of HIV-1+ Puerto Ricans: 2002–2011" @default.
• W2612650019 cites W1526829546 @default.
• W2612650019 cites W1741430525 @default.
• W2612650019 cites W1916879247 @default.
• W2612650019 cites W1986400554 @default.
• W2612650019 cites W2002086907 @default.
• W2612650019 cites W2002705151 @default.
• W2612650019 cites W2004345778 @default.
• W2612650019 cites W2012162740 @default.
• W2612650019 cites W2012850158 @default.
• W2612650019 cites W2020780549 @default.
• W2612650019 cites W2051042670 @default.
• W2612650019 cites W2061869190 @default.
• W2612650019 cites W2066033112 @default.
• W2612650019 cites W2069388608 @default.
• W2612650019 cites W2083829212 @default.
• W2612650019 cites W2118000026 @default.
• W2612650019 cites W2120305569 @default.
• W2612650019 cites W2120536879 @default.
• W2612650019 cites W2129294673 @default.
• W2612650019 cites W2136873830 @default.
• W2612650019 cites W2148750104 @default.
• W2612650019 cites W2152505869 @default.
• W2612650019 cites W2155676461 @default.
• W2612650019 cites W2155782061 @default.
• W2612650019 cites W2163166304 @default.
• W2612650019 cites W2201022636 @default.
• W2612650019 cites W2238552371 @default.
• W2612650019 cites W2271871949 @default.
• W2612650019 cites W2292461890 @default.
• W2612650019 cites W2339873888 @default.
• W2612650019 cites W2342838186 @default.
• W2612650019 cites W2396474699 @default.
• W2612650019 cites W2400580124 @default.
• W2612650019 cites W2417778102 @default.
• W2612650019 cites W2466714343 @default.
• W2612650019 cites W2562231527 @default.
• W2612650019 cites W2625924212 @default.
• W2612650019 cites W2915553982 @default.
• W2612650019 cites W2916981229 @default.
• W2612650019 cites W2917119881 @default.
• W2612650019 cites W2993333632 @default.
• W2612650019 cites W4240243247 @default.
• W2612650019 cites W4298240359 @default.
• W2612650019 doi "https://doi.org/10.1371/journal.pone.0177452" @default.
• W2612650019 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5426751" @default.
• W2612650019 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28493944" @default.
• W2612650019 hasPublicationYear "2017" @default.
• W2612650019 type Work @default.
• W2612650019 sameAs 2612650019 @default.
• W2612650019 citedByCount "4" @default.
• W2612650019 countsByYear W26126500192018 @default.
• W2612650019 countsByYear W26126500192021 @default.
• W2612650019 crossrefType "journal-article" @default.
• W2612650019 hasAuthorship W2612650019A5031916073 @default.
• W2612650019 hasAuthorship W2612650019A5056585290 @default.
• W2612650019 hasAuthorship W2612650019A5062048502 @default.
• W2612650019 hasAuthorship W2612650019A5066604159 @default.
• W2612650019 hasAuthorship W2612650019A5070187831 @default.
• W2612650019 hasAuthorship W2612650019A5070688663 @default.
• W2612650019 hasAuthorship W2612650019A5077617304 @default.
• W2612650019 hasBestOaLocation W26126500191 @default.
• W2612650019 hasConcept C104317684 @default.
• W2612650019 hasConcept C114851261 @default.
• W2612650019 hasConcept C135763542 @default.
• W2612650019 hasConcept C142462285 @default.
• W2612650019 hasConcept C156719811 @default.
• W2612650019 hasConcept C159047783 @default.
• W2612650019 hasConcept C182707283 @default.
• W2612650019 hasConcept C2778451633 @default.
• W2612650019 hasConcept C2908647359 @default.
• W2612650019 hasConcept C2993143319 @default.
• W2612650019 hasConcept C3013748606 @default.
• W2612650019 hasConcept C31467283 @default.
• W2612650019 hasConcept C49105822 @default.
• W2612650019 hasConcept C501734568 @default.
• W2612650019 hasConcept C54355233 @default.
• W2612650019 hasConcept C71924100 @default.
• W2612650019 hasConcept C86803240 @default.
• W2612650019 hasConcept C98638677 @default.
• W2612650019 hasConcept C99454951 @default.
• W2612650019 hasConceptScore W2612650019C104317684 @default.
• W2612650019 hasConceptScore W2612650019C114851261 @default.
• W2612650019 hasConceptScore W2612650019C135763542 @default.
• W2612650019 hasConceptScore W2612650019C142462285 @default.
• W2612650019 hasConceptScore W2612650019C156719811 @default.
• W2612650019 hasConceptScore W2612650019C159047783 @default.

• next