FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2612784796> ?p ?o ?g. }

• W2612784796 abstract "Event Abstract Back to Event Neural correlates of longitudinal recovery of naming in stroke Rajani Sebastian1*, Charltien Long2, Jeremy Purcell1, 3, David Race1, Cameron Davis1, Joseph Posner1 and Argye Hillis1, 3, 4 1 Johns Hopkins University School of Medicine, Department of Neurology, United States 2 Johns Hopkins University, Department of Neuroscience, United States 3 Johns Hopkins University, Department of Cognitive Science, United States 4 Johns Hopkins University School of Medicine, Department of Physical Medicine and Rehabilitation, United States Introduction: The neural mechanisms that support aphasia recovery are not yet fully understood. A previous, longitudinal fMRI study of language recovery in stoke patients using auditory comprehension task found that aphasia recovery is characterized by: little activation (in either hemisphere) during the acute phase; a large increase in activation in the bilateral network; and a shift of language back to the left hemispheric in the chronic phase (Saur et al., 2006). However, it is unclear whether other language tasks would show a similar time course in recovery and whether there would be individual differences in the recovery pattern. Our aim in the current study was to investigate the neural correlates of recovery of naming from the acute to chronic stage. Methods: 6 right-handed participants with acute ischemic left hemisphere stroke (mean age: 53.1 years) and 2 normal controls (mean age: 52.5 years) with no history of neurological disorder were enrolled in this study. All stroke patients had clinical scans within 24 hours of symptom onset. Participants received detailed language testing and research scans (MPRAGE and BOLD) at 4 time points (acute, 2-5 weeks, 4-7 months, and 11-13 months). The fMRI task was a cued picture-naming task (Holland et al., 2011). Each picture was presented concurrently with an auditory cue, which was either: (i) a whole word (ii) an initial phoneme or (iii) an unintelligible auditory noise. The control condition consisted of viewing scrambled pictures. Trials were presented in short blocks of six pictures, separated by the control condition of 7 s. fMRI data were preprocessed and analyzed in FSL (Smith et al., 2004; Jenkinson et al., 2012). Contrast compared picture naming (initial+word cues) to control condition. Results: Successful overt picture naming in the normal controls involved a bilateral fronto-temporal, parietal and occipital network at all time points. All patients showed bilateral activation in the temporo-parietal and/or frontal regions at the acute time point. Follow up scans revealed different recovery patterns for the patients. For example, follow up scanning for P3 did not show any significant change from the acute stage, although her naming ability had markedly improved. P4’s naming ability continued to improve at the follow up time points with a corresponding increase in left hemisphere activation at the follow up time points (see Figure 1). Conclusion: Our preliminary data suggests that recovery of naming is dynamic and may have different time courses in different individuals. Further, brain reorganization during language recovery may not proceed in three phases as proposed by Saur and colleagues. This finding is in line with the recent work from our lab, which examined recovery of language within the first two months after a stroke (Jarso et al., 2014). To further understand the processes involved in naming recovery, we are analyzing DTI and resting state fMRI data. It is hoped that the results from the multimodality imaging data will serve as the basis for targeted brain-based interventions for aphasia, which require an understanding of the anatomy of language networks, as well as the extent and timing of how these networks reorganize after injury. Figure 1 Acknowledgements This research study was supported by NIDCD-RO1 DC 005375-1 References Holland, R., Leff, A. P., Josephs, O., Galea, J. M., Desikan, M., Price, C. J., ... & Crinion, J. (2011). Speech facilitation by left inferior frontal cortex stimulation. Current Biology, 21(16), 1403-1407. Jarso, S., Li, M., Faria, A., Davis, C., Leigh, R., Sebastian, R., ... & Hillis, A. E. (2013). Distinct mechanisms and timing of language recovery after stroke. Cognitive neuropsychology, 30(7-8), 454-475. Jenkinson, M., Beckmann, C. F., Behrens, T. E., Woolrich, M. W., & Smith, S. M. (2012). FSL. Neuroimage, 62(2), 782-790. Saur, D., Lange, R., Baumgaertner, A., Schraknepper, V., Willmes, K., Rijntjes, M., & Weiller, C. (2006). Dynamics of language reorganization after stroke. Brain, 129(6), 137. Smith, S. M., Jenkinson, M., Woolrich, M. W., Beckmann, C. F., Behrens, T. E., Johansen-Berg, H., ... & Matthews, P. M. (2004). Advances in functional and structural MR image analysis and implementation as FSL. Neuroimage, 23, S208-S219. Keywords: acute stroke, Longitudinal, Naming Recovery, fMRI, Aphasia Conference: Academy of Aphasia 53rd Annual Meeting, Tucson, United States, 18 Oct - 20 Oct, 2015. Presentation Type: symposium Topic: Not student first author Citation: Sebastian R, Long C, Purcell J, Race D, Davis C, Posner J and Hillis A (2015). Neural correlates of longitudinal recovery of naming in stroke. Front. Psychol. Conference Abstract: Academy of Aphasia 53rd Annual Meeting. doi: 10.3389/conf.fpsyg.2015.65.00035 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 01 May 2015; Published Online: 24 Sep 2015. * Correspondence: Dr. Rajani Sebastian, Johns Hopkins University School of Medicine, Department of Neurology, Baltimore, Maryland, United States, rsebast3@jhmi.edu Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Rajani Sebastian Charltien Long Jeremy Purcell David Race Cameron Davis Joseph Posner Argye Hillis Google Rajani Sebastian Charltien Long Jeremy Purcell David Race Cameron Davis Joseph Posner Argye Hillis Google Scholar Rajani Sebastian Charltien Long Jeremy Purcell David Race Cameron Davis Joseph Posner Argye Hillis PubMed Rajani Sebastian Charltien Long Jeremy Purcell David Race Cameron Davis Joseph Posner Argye Hillis Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page." @default.
• W2612784796 created "2017-05-19" @default.
• W2612784796 creator A5001493546 @default.
• W2612784796 creator A5023787382 @default.
• W2612784796 creator A5027589471 @default.
• W2612784796 creator A5031629360 @default.
• W2612784796 creator A5040882688 @default.
• W2612784796 creator A5061325064 @default.
• W2612784796 creator A5083673431 @default.
• W2612784796 date "2015-01-01" @default.
• W2612784796 modified "2023-09-26" @default.
• W2612784796 title "Neural correlates of longitudinal recovery of naming in stroke" @default.
• W2612784796 doi "https://doi.org/10.3389/conf.fpsyg.2015.65.00035" @default.
• W2612784796 hasPublicationYear "2015" @default.
• W2612784796 type Work @default.
• W2612784796 sameAs 2612784796 @default.
• W2612784796 citedByCount "0" @default.
• W2612784796 crossrefType "journal-article" @default.
• W2612784796 hasAuthorship W2612784796A5001493546 @default.
• W2612784796 hasAuthorship W2612784796A5023787382 @default.
• W2612784796 hasAuthorship W2612784796A5027589471 @default.
• W2612784796 hasAuthorship W2612784796A5031629360 @default.
• W2612784796 hasAuthorship W2612784796A5040882688 @default.
• W2612784796 hasAuthorship W2612784796A5061325064 @default.
• W2612784796 hasAuthorship W2612784796A5083673431 @default.
• W2612784796 hasBestOaLocation W26127847961 @default.
• W2612784796 hasConcept C127413603 @default.
• W2612784796 hasConcept C129564537 @default.
• W2612784796 hasConcept C15744967 @default.
• W2612784796 hasConcept C169760540 @default.
• W2612784796 hasConcept C169900460 @default.
• W2612784796 hasConcept C180747234 @default.
• W2612784796 hasConcept C2776361831 @default.
• W2612784796 hasConcept C2778818304 @default.
• W2612784796 hasConcept C2780645631 @default.
• W2612784796 hasConcept C78519656 @default.
• W2612784796 hasConceptScore W2612784796C127413603 @default.
• W2612784796 hasConceptScore W2612784796C129564537 @default.
• W2612784796 hasConceptScore W2612784796C15744967 @default.
• W2612784796 hasConceptScore W2612784796C169760540 @default.
• W2612784796 hasConceptScore W2612784796C169900460 @default.
• W2612784796 hasConceptScore W2612784796C180747234 @default.
• W2612784796 hasConceptScore W2612784796C2776361831 @default.
• W2612784796 hasConceptScore W2612784796C2778818304 @default.
• W2612784796 hasConceptScore W2612784796C2780645631 @default.
• W2612784796 hasConceptScore W2612784796C78519656 @default.
• W2612784796 hasLocation W26127847961 @default.
• W2612784796 hasOpenAccess W2612784796 @default.
• W2612784796 hasPrimaryLocation W26127847961 @default.
• W2612784796 hasRelatedWork W2004009495 @default.
• W2612784796 hasRelatedWork W2070426261 @default.
• W2612784796 hasRelatedWork W2085642841 @default.
• W2612784796 hasRelatedWork W2093287941 @default.
• W2612784796 hasRelatedWork W2107641489 @default.
• W2612784796 hasRelatedWork W2340536965 @default.
• W2612784796 hasRelatedWork W2513428240 @default.
• W2612784796 hasRelatedWork W2792903782 @default.
• W2612784796 hasRelatedWork W3148860545 @default.
• W2612784796 hasRelatedWork W4246780736 @default.
• W2612784796 hasVolume "6" @default.
• W2612784796 isParatext "false" @default.
• W2612784796 isRetracted "false" @default.
• W2612784796 magId "2612784796" @default.
• W2612784796 workType "article" @default.