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- W2612805833 abstract "Dental plaques are mixed-species biofilms that are related to the development of dental caries. Streptococcus mutans (S. mutans) is an important cariogenic bacterium that forms mixed-species biofilms with Streptococcus gordonii (S. gordonii), an early colonizer of the tooth surface. The LuxS/autoinducer-2(AI-2) quorum sensing system is involved in the regulation of mixed-species biofilms, and AI-2 is proposed as a universal signal for the interaction between bacterial species. In this work, a S. gordonii luxS deficient strain was constructed to investigate the effect of the S. gordonii luxS gene on dual-species biofilm formed by S. mutans and S. gordonii. In addition, AI-2 was synthesized in vitro by incubating recombinant LuxS and Pfs enzymes of S. gordonii together. The effect of AI-2 on S. mutans single-species biofilm formation and cariogenic virulence gene expression were also assessed. The results showed that luxS disruption in S. gordonii altered dual-species biofilm formation, architecture, and composition, as well as the susceptibility to chlorhexidine. And the in vitro synthesized AI-2 had a concentration-dependent effect on S. mutans biofilm formation and virulence gene expression. These findings indicate that LuxS/AI-2 quorum-sensing system of S. gordonii plays a role in regulating the dual-species biofilm formation with S. mutans." @default.
- W2612805833 created "2017-05-19" @default.
- W2612805833 creator A5014785245 @default.
- W2612805833 creator A5069150969 @default.
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- W2612805833 date "2017-05-09" @default.
- W2612805833 modified "2023-10-05" @default.
- W2612805833 title "<i>Streptococcus gordonii</i> LuxS/autoinducer-2 quorum-sensing system modulates the dual-species biofilm formation with <i>Streptococcus mutans</i>" @default.
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- W2612805833 doi "https://doi.org/10.1002/jobm.201700010" @default.
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