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- W2612849144 abstract "A osteoartrite (OA) é a forma mais comum de artrite e frequentemente é diagnosticada e gerenciada na atenção primária; é caracterizada por perda da cartilagem articular hialina, um tecido conjuntivo único que fisiologicamente carece de vasos sanguíneos. A cartilagem articular sobrevive em um microambiente desprovido de oxigênio, que é regulado pelo fator induzível por hipóxia‐1α (HIF‐1α). O HIF‐1α é considerado o principal regulador transcricional da resposta celular e de desenvolvimento à hipóxia. Na atualidade, a relevância do HIF‐1α na avaliação da cartilagem tem aumentado, já que a sua participação é essencial na homeostase desse tecido. Considerando as novas perspectivas emergentes do HIF‐1α na literatura científica nos últimos anos, foca‐se a presente revisão no potencial papel da via de sinalização do HIF‐1α no desenvolvimento da OA, especialmente no modo como alguns fatores genéticos podem influenciar na manutenção ou ruptura da cartilagem articular. Osteoarthritis (OA) is the most common form of arthritis and is frequently diagnosed and managed in primary care; it is characterized by loss of articular hyaline cartilage, which is a unique connective tissue that physiologically lacks blood vessels. Articular cartilage survives in a microenvironment devoid of oxygen, which is regulated by hypoxia inducible factor (HIF‐1α). HIF‐1α is considered the main transcriptional regulator of cellular and developmental response to hypoxia. To date, the relevance of HIF‐1α in the assessment of cartilage has increased since its participation is essential in the homeostasis of this tissue. Taking into account the new emerging insights of HIF‐1α in the scientific literature in the last years, we focused the present review on the potential role of HIF‐1α signaling pathway in OA development, especially in how some genetic factors may influence the maintenance or breakdown of articular cartilage." @default.
- W2612849144 created "2017-05-19" @default.
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- W2612849144 date "2017-03-01" @default.
- W2612849144 modified "2023-10-18" @default.
- W2612849144 title "Papel da via de sinalização do HIF‐1α na osteoartrite: revisão sistemática" @default.
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- W2612849144 doi "https://doi.org/10.1016/j.rbr.2016.04.006" @default.
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