Matches in SemOpenAlex for { <https://semopenalex.org/work/W2612934650> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W2612934650 abstract "Heart failure is the leading cause of morbidity and mortality worldwide. Adult cardiomyocytes are post-mitotic cells that are substantially refractory to re-enter the cell cycle. This is exemplified by the absence of significant proliferative potential in differentiated cardiomyocytes. When exposed to aberrant growth stimuli, cardiomyocytes undergo maladaptive changes characterized by hypertrophic growth. The existing armamentarium of conventional pharmacological therapy can only slow the progression of the disease by alleviating the workload of the heart. Various agonist- and stress-induced extracellular signal transduction pathways could be target by novel agents for the treatment of pathological cardiac growth. Among these, the cyclin-dependent kinase inhibitors p21 and p27 have been recognized as potent inhibitors of apoptosis, growth and proliferation in cardiovascular disease. The role of the cell cycle factors p21 and p27 in the regulation of growth-associated processes in the heart, and their potential therapeutic implications are not immediately obvious, as it is the case in cardiovascular biology. In this review, we focus on the multiple functions of p21 and p27 in the regulation of hypertrophy, and briefly discuss pathways that play critical play therein. All these selected studies attest an important role of p21 and p27 in the regulation of hypertrophy in isolated rat cardiomyocytes, and in various genetic murine models of heart failure. The available evidence suggests that therapeutic clinical approaches involving p21 and p27 have the potential to to treat heart failure in patients." @default.
- W2612934650 created "2017-05-19" @default.
- W2612934650 creator A5010513524 @default.
- W2612934650 creator A5019669093 @default.
- W2612934650 creator A5023507476 @default.
- W2612934650 date "2018-05-21" @default.
- W2612934650 modified "2023-09-24" @default.
- W2612934650 title "An emerging role for the Cdk-inhibitors p21Cip1/Waf1 and p27Kip1 as potential therapies for the treatment of cardiac hypertrophy" @default.
- W2612934650 doi "https://doi.org/10.14800/crm.1527" @default.
- W2612934650 hasPublicationYear "2018" @default.
- W2612934650 type Work @default.
- W2612934650 sameAs 2612934650 @default.
- W2612934650 citedByCount "0" @default.
- W2612934650 crossrefType "journal-article" @default.
- W2612934650 hasAuthorship W2612934650A5010513524 @default.
- W2612934650 hasAuthorship W2612934650A5019669093 @default.
- W2612934650 hasAuthorship W2612934650A5023507476 @default.
- W2612934650 hasConcept C121608353 @default.
- W2612934650 hasConcept C124320809 @default.
- W2612934650 hasConcept C126322002 @default.
- W2612934650 hasConcept C167414201 @default.
- W2612934650 hasConcept C2778198053 @default.
- W2612934650 hasConcept C2778298596 @default.
- W2612934650 hasConcept C2779134260 @default.
- W2612934650 hasConcept C29537977 @default.
- W2612934650 hasConcept C502942594 @default.
- W2612934650 hasConcept C54355233 @default.
- W2612934650 hasConcept C62112901 @default.
- W2612934650 hasConcept C62478195 @default.
- W2612934650 hasConcept C71924100 @default.
- W2612934650 hasConcept C86803240 @default.
- W2612934650 hasConcept C95444343 @default.
- W2612934650 hasConceptScore W2612934650C121608353 @default.
- W2612934650 hasConceptScore W2612934650C124320809 @default.
- W2612934650 hasConceptScore W2612934650C126322002 @default.
- W2612934650 hasConceptScore W2612934650C167414201 @default.
- W2612934650 hasConceptScore W2612934650C2778198053 @default.
- W2612934650 hasConceptScore W2612934650C2778298596 @default.
- W2612934650 hasConceptScore W2612934650C2779134260 @default.
- W2612934650 hasConceptScore W2612934650C29537977 @default.
- W2612934650 hasConceptScore W2612934650C502942594 @default.
- W2612934650 hasConceptScore W2612934650C54355233 @default.
- W2612934650 hasConceptScore W2612934650C62112901 @default.
- W2612934650 hasConceptScore W2612934650C62478195 @default.
- W2612934650 hasConceptScore W2612934650C71924100 @default.
- W2612934650 hasConceptScore W2612934650C86803240 @default.
- W2612934650 hasConceptScore W2612934650C95444343 @default.
- W2612934650 hasLocation W26129346501 @default.
- W2612934650 hasOpenAccess W2612934650 @default.
- W2612934650 hasPrimaryLocation W26129346501 @default.
- W2612934650 hasRelatedWork W151680342 @default.
- W2612934650 hasRelatedWork W1989434611 @default.
- W2612934650 hasRelatedWork W1998503381 @default.
- W2612934650 hasRelatedWork W2009867523 @default.
- W2612934650 hasRelatedWork W2014201708 @default.
- W2612934650 hasRelatedWork W2027323397 @default.
- W2612934650 hasRelatedWork W2079267137 @default.
- W2612934650 hasRelatedWork W2080811589 @default.
- W2612934650 hasRelatedWork W2112087264 @default.
- W2612934650 hasRelatedWork W2134895988 @default.
- W2612934650 hasRelatedWork W2140417829 @default.
- W2612934650 hasRelatedWork W2284834690 @default.
- W2612934650 hasRelatedWork W2756139140 @default.
- W2612934650 hasRelatedWork W2784004570 @default.
- W2612934650 hasRelatedWork W2922173784 @default.
- W2612934650 hasRelatedWork W295353521 @default.
- W2612934650 hasRelatedWork W3191508785 @default.
- W2612934650 hasRelatedWork W3198111067 @default.
- W2612934650 hasRelatedWork W2014381500 @default.
- W2612934650 hasRelatedWork W3096988840 @default.
- W2612934650 isParatext "false" @default.
- W2612934650 isRetracted "false" @default.
- W2612934650 magId "2612934650" @default.
- W2612934650 workType "article" @default.