FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2613162022> ?p ?o ?g. }

• W2613162022 endingPage "466" @default.
• W2613162022 startingPage "461" @default.
• W2613162022 abstract "The unique, unphysiological Fontan circulation is associated with an impaired functional status of the patients that is suggested to deteriorate over time. Unfortunately, previous studies did not integrate both pulmonary and cardiac determinants of functional status. In addition, a comparison with the natural decrease in exercise capacity in healthy subjects (in both children and adults) is lacking. This single-center study aims to investigate the functional status in a cohort of Fontan patients in relation to time since Fontan completion and to identify its determinants, including cardiac characteristics and pulmonary characteristics. Eighty-five consecutive Fontan patients ≥10 years who performed adequate cardiopulmonary exercise testing (respiratory exchange ratio >1.01) were included. Mean time since Fontan completion was 15 ± 9 years (range 2 to 37 years). New York Heart Association functional class was I in 36 patients (42%), II in 41 patients (48%), and III in 8 patients (9%). Peak oxygen uptake during exercise (VO2 index) was 25.7 ± 7.9 ml/min/m2 (58 ± 14% of predicted). New York Heart Association functional class and peak VO2 index both correlated with time since the Fontan operation; however, peak VO2 as percentage of predicted (VO2(pred)) did not. In multivariate analyses, peak VO2(pred) was independently associated with maximum heart rate, oxygen pulse at peak exercise, and forced expiratory volume in 1 second (R2 = 0.579) but not with cardiac output in rest. In conclusion, the present data suggest that functional status in Fontan patients is impaired already shortly after Fontan completion, whereas its subsequent deterioration seems to follow the natural decline of aging. Furthermore, functional status in Fontan patients correlates with pulmonary function and cardiac functional parameters during exercise but not with conventional cardiac measurements at rest. The unique, unphysiological Fontan circulation is associated with an impaired functional status of the patients that is suggested to deteriorate over time. Unfortunately, previous studies did not integrate both pulmonary and cardiac determinants of functional status. In addition, a comparison with the natural decrease in exercise capacity in healthy subjects (in both children and adults) is lacking. This single-center study aims to investigate the functional status in a cohort of Fontan patients in relation to time since Fontan completion and to identify its determinants, including cardiac characteristics and pulmonary characteristics. Eighty-five consecutive Fontan patients ≥10 years who performed adequate cardiopulmonary exercise testing (respiratory exchange ratio >1.01) were included. Mean time since Fontan completion was 15 ± 9 years (range 2 to 37 years). New York Heart Association functional class was I in 36 patients (42%), II in 41 patients (48%), and III in 8 patients (9%). Peak oxygen uptake during exercise (VO2 index) was 25.7 ± 7.9 ml/min/m2 (58 ± 14% of predicted). New York Heart Association functional class and peak VO2 index both correlated with time since the Fontan operation; however, peak VO2 as percentage of predicted (VO2(pred)) did not. In multivariate analyses, peak VO2(pred) was independently associated with maximum heart rate, oxygen pulse at peak exercise, and forced expiratory volume in 1 second (R2 = 0.579) but not with cardiac output in rest. In conclusion, the present data suggest that functional status in Fontan patients is impaired already shortly after Fontan completion, whereas its subsequent deterioration seems to follow the natural decline of aging. Furthermore, functional status in Fontan patients correlates with pulmonary function and cardiac functional parameters during exercise but not with conventional cardiac measurements at rest." @default.
• W2613162022 created "2017-05-19" @default.
• W2613162022 creator A5008852859 @default.
• W2613162022 creator A5017239261 @default.
• W2613162022 creator A5031364797 @default.
• W2613162022 creator A5031799162 @default.
• W2613162022 creator A5033537614 @default.
• W2613162022 creator A5033653473 @default.
• W2613162022 creator A5051048026 @default.
• W2613162022 creator A5056531628 @default.
• W2613162022 creator A5069961126 @default.
• W2613162022 creator A5076679420 @default.
• W2613162022 creator A5078571650 @default.
• W2613162022 creator A5088799155 @default.
• W2613162022 date "2017-08-01" @default.
• W2613162022 modified "2023-09-23" @default.
• W2613162022 title "Fontan Circulation over Time" @default.
• W2613162022 cites W1524688258 @default.
• W2613162022 cites W1971263358 @default.
• W2613162022 cites W1980374074 @default.
• W2613162022 cites W2029222165 @default.
• W2613162022 cites W2041530795 @default.
• W2613162022 cites W2072371345 @default.
• W2613162022 cites W2083431496 @default.
• W2613162022 cites W2094797036 @default.
• W2613162022 cites W2099449365 @default.
• W2613162022 cites W2105612502 @default.
• W2613162022 cites W2105890402 @default.
• W2613162022 cites W2108718449 @default.
• W2613162022 cites W2113945894 @default.
• W2613162022 cites W2114934609 @default.
• W2613162022 cites W2115515445 @default.
• W2613162022 cites W2120495926 @default.
• W2613162022 cites W2126589135 @default.
• W2613162022 cites W2127188787 @default.
• W2613162022 cites W2129975409 @default.
• W2613162022 cites W2154665054 @default.
• W2613162022 cites W2155537733 @default.
• W2613162022 cites W2165543134 @default.
• W2613162022 cites W2165762779 @default.
• W2613162022 cites W2170448649 @default.
• W2613162022 cites W30502014 @default.
• W2613162022 cites W4251936846 @default.
• W2613162022 doi "https://doi.org/10.1016/j.amjcard.2017.05.005" @default.
• W2613162022 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28624095" @default.
• W2613162022 hasPublicationYear "2017" @default.
• W2613162022 type Work @default.
• W2613162022 sameAs 2613162022 @default.
• W2613162022 citedByCount "12" @default.
• W2613162022 countsByYear W26131620222018 @default.
• W2613162022 countsByYear W26131620222019 @default.
• W2613162022 countsByYear W26131620222020 @default.
• W2613162022 countsByYear W26131620222021 @default.
• W2613162022 countsByYear W26131620222023 @default.
• W2613162022 crossrefType "journal-article" @default.
• W2613162022 hasAuthorship W2613162022A5008852859 @default.
• W2613162022 hasAuthorship W2613162022A5017239261 @default.
• W2613162022 hasAuthorship W2613162022A5031364797 @default.
• W2613162022 hasAuthorship W2613162022A5031799162 @default.
• W2613162022 hasAuthorship W2613162022A5033537614 @default.
• W2613162022 hasAuthorship W2613162022A5033653473 @default.
• W2613162022 hasAuthorship W2613162022A5051048026 @default.
• W2613162022 hasAuthorship W2613162022A5056531628 @default.
• W2613162022 hasAuthorship W2613162022A5069961126 @default.
• W2613162022 hasAuthorship W2613162022A5076679420 @default.
• W2613162022 hasAuthorship W2613162022A5078571650 @default.
• W2613162022 hasAuthorship W2613162022A5088799155 @default.
• W2613162022 hasBestOaLocation W26131620222 @default.
• W2613162022 hasConcept C126322002 @default.
• W2613162022 hasConcept C139940330 @default.
• W2613162022 hasConcept C164705383 @default.
• W2613162022 hasConcept C178853913 @default.
• W2613162022 hasConcept C196310339 @default.
• W2613162022 hasConcept C2776974648 @default.
• W2613162022 hasConcept C2777953023 @default.
• W2613162022 hasConcept C2778212704 @default.
• W2613162022 hasConcept C2780074459 @default.
• W2613162022 hasConcept C31861589 @default.
• W2613162022 hasConcept C71924100 @default.
• W2613162022 hasConcept C72563966 @default.
• W2613162022 hasConcept C84393581 @default.
• W2613162022 hasConceptScore W2613162022C126322002 @default.
• W2613162022 hasConceptScore W2613162022C139940330 @default.
• W2613162022 hasConceptScore W2613162022C164705383 @default.
• W2613162022 hasConceptScore W2613162022C178853913 @default.
• W2613162022 hasConceptScore W2613162022C196310339 @default.
• W2613162022 hasConceptScore W2613162022C2776974648 @default.
• W2613162022 hasConceptScore W2613162022C2777953023 @default.
• W2613162022 hasConceptScore W2613162022C2778212704 @default.
• W2613162022 hasConceptScore W2613162022C2780074459 @default.
• W2613162022 hasConceptScore W2613162022C31861589 @default.
• W2613162022 hasConceptScore W2613162022C71924100 @default.
• W2613162022 hasConceptScore W2613162022C72563966 @default.
• W2613162022 hasConceptScore W2613162022C84393581 @default.
• W2613162022 hasIssue "3" @default.
• W2613162022 hasLocation W26131620221 @default.
• W2613162022 hasLocation W26131620222 @default.
• W2613162022 hasLocation W26131620223 @default.

• next