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- W2613204574 abstract "Abstract Galectin‐1 is a tumor‐associated protein recognizing the Galβ1‐4GlcNAc motif of cell‐surface glycoconjugates. Herein, we report the stepwise expansion of a multifunctional natural scaffold based on N ‐acetyllactosamine (Lac N Ac). We obtained a Lac N Ac mimetic equipped with an alkynyl function on the 3′‐hydroxy group of the disaccharide facing towards a binding pocket adjacent to the carbohydrate‐recognition domain. It served as an anchor motif for further expansion by the Sharpless–Huisgen–Meldal reaction, which resulted in ligands with a binding mode almost identical to that of the natural carbohydrate template. X‐ray crystallography provided a structural understanding of the galectin‐1–ligand interactions. The results of this study enable the development of bespoke ligands for members of the galectin target family." @default.
- W2613204574 created "2017-05-19" @default.
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- W2613204574 date "2017-06-22" @default.
- W2613204574 modified "2023-10-01" @default.
- W2613204574 title "Exploring the Structural Space of the Galectin-1-Ligand Interaction" @default.
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- W2613204574 doi "https://doi.org/10.1002/cbic.201700251" @default.
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