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• W2613209849 abstract "Hydrogen peroxide (H2O2) controls signaling pathways in cells by oxidative modulation of the activity of redox sensitive proteins denominated redox switches. Here, quantitative biology concepts are applied to review how H2O2 fulfills a key role in information transmission. Equations described lay the foundation of H2O2 signaling, give new insights on H2O2 signaling mechanisms, and help to learn new information from common redox signaling experiments. A key characteristic of H2O2 signaling is that the ratio between reduction and oxidation of redox switches determines the range of H2O2 concentrations to which they respond. Thus, a redox switch with low H2O2-dependent oxidability and slow reduction rate responds to the same range of H2O2 concentrations as a redox switch with high H2O2-dependent oxidability, but that is rapidly reduced. Yet, in the first case the response time is slow while in the second case is rapid. H2O2 sensing and transmission of information can be done directly or by complex mechanisms in which oxidation is relayed between proteins before oxidizing the final regulatory redox target. In spite of being a very simple molecule, H2O2 has a key role in cellular signaling, with the reliability of the information transmitted depending on the inherent chemical reactivity of redox switches, on the presence of localized H2O2 pools, and on the molecular recognition between redox switches and their partners." @default.
• W2613209849 created "2017-05-19" @default.
• W2613209849 creator A5008225569 @default.
• W2613209849 creator A5015138948 @default.
• W2613209849 date "2017-10-01" @default.
• W2613209849 modified "2023-10-12" @default.
• W2613209849 title "Quantitative biology of hydrogen peroxide signaling" @default.
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• W2613209849 doi "https://doi.org/10.1016/j.redox.2017.04.039" @default.
• W2613209849 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5436100" @default.
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• W2613209849 hasPublicationYear "2017" @default.
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