FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2613273453> ?p ?o ?g. }

• W2613273453 endingPage "2018" @default.
• W2613273453 startingPage "2011" @default.
• W2613273453 abstract "Epithelial injury induces rapid recruitment of antimicrobial leukocytes to the wound site. In zebrafish larvae, activation of the epithelial NADPH oxidase Duox at the wound margin is required early during this response. Before injury, leukocytes are near the vascular region, that is, ∼100–300 μm away from the injury site. How Duox establishes long-range signaling to leukocytes is unclear. We conceived that extracellular hydrogen peroxide (H2O2) generated by Duox diffuses through the tissue to directly regulate chemotactic signaling in these cells. But before it can oxidize cellular proteins, H2O2 must get past the antioxidant barriers that protect the cellular proteome. To test whether, or on which length scales this occurs during physiological wound signaling, we developed a computational method based on reaction-diffusion principles that infers H2O2 degradation rates from intravital H2O2-biosensor imaging data. Our results indicate that at high tissue H2O2 levels the peroxiredoxin-thioredoxin antioxidant chain becomes overwhelmed, and H2O2 degradation stalls or ceases. Although the wound H2O2 gradient reaches deep into the tissue, it likely overcomes antioxidant barriers only within ∼30 μm of the wound margin. Thus, Duox-mediated long-range signaling may require other spatial relay mechanisms besides extracellular H2O2 diffusion." @default.
• W2613273453 created "2017-05-19" @default.
• W2613273453 creator A5028819015 @default.
• W2613273453 creator A5033730595 @default.
• W2613273453 creator A5054108205 @default.
• W2613273453 creator A5055213896 @default.
• W2613273453 date "2017-05-01" @default.
• W2613273453 modified "2023-09-28" @default.
• W2613273453 title "Image-Based Measurement of H 2 O 2 Reaction-Diffusion in Wounded Zebrafish Larvae" @default.
• W2613273453 cites W114440940 @default.
• W2613273453 cites W1489361755 @default.
• W2613273453 cites W1970391341 @default.
• W2613273453 cites W1971717625 @default.
• W2613273453 cites W1975084717 @default.
• W2613273453 cites W1986320576 @default.
• W2613273453 cites W1989599722 @default.
• W2613273453 cites W1992740290 @default.
• W2613273453 cites W1994211699 @default.
• W2613273453 cites W1995984781 @default.
• W2613273453 cites W1999008171 @default.
• W2613273453 cites W2002051280 @default.
• W2613273453 cites W2002356275 @default.
• W2613273453 cites W2008203769 @default.
• W2613273453 cites W2008820074 @default.
• W2613273453 cites W2009476974 @default.
• W2613273453 cites W2017642315 @default.
• W2613273453 cites W2027827026 @default.
• W2613273453 cites W2069463594 @default.
• W2613273453 cites W2084480002 @default.
• W2613273453 cites W2088411222 @default.
• W2613273453 cites W2112645157 @default.
• W2613273453 cites W2115708356 @default.
• W2613273453 cites W2122019197 @default.
• W2613273453 cites W2132725786 @default.
• W2613273453 cites W2133210319 @default.
• W2613273453 cites W2142320355 @default.
• W2613273453 cites W2167279371 @default.
• W2613273453 cites W2168990618 @default.
• W2613273453 cites W2190326963 @default.
• W2613273453 cites W2345986387 @default.
• W2613273453 cites W2415997688 @default.
• W2613273453 cites W2467426346 @default.
• W2613273453 doi "https://doi.org/10.1016/j.bpj.2017.03.021" @default.
• W2613273453 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5425381" @default.
• W2613273453 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28494970" @default.
• W2613273453 hasPublicationYear "2017" @default.
• W2613273453 type Work @default.
• W2613273453 sameAs 2613273453 @default.
• W2613273453 citedByCount "25" @default.
• W2613273453 countsByYear W26132734532017 @default.
• W2613273453 countsByYear W26132734532018 @default.
• W2613273453 countsByYear W26132734532019 @default.
• W2613273453 countsByYear W26132734532020 @default.
• W2613273453 countsByYear W26132734532021 @default.
• W2613273453 countsByYear W26132734532022 @default.
• W2613273453 countsByYear W26132734532023 @default.
• W2613273453 crossrefType "journal-article" @default.
• W2613273453 hasAuthorship W2613273453A5028819015 @default.
• W2613273453 hasAuthorship W2613273453A5033730595 @default.
• W2613273453 hasAuthorship W2613273453A5054108205 @default.
• W2613273453 hasAuthorship W2613273453A5055213896 @default.
• W2613273453 hasBestOaLocation W26132734531 @default.
• W2613273453 hasConcept C104317684 @default.
• W2613273453 hasConcept C12554922 @default.
• W2613273453 hasConcept C162008176 @default.
• W2613273453 hasConcept C170493617 @default.
• W2613273453 hasConcept C181199279 @default.
• W2613273453 hasConcept C185592680 @default.
• W2613273453 hasConcept C203014093 @default.
• W2613273453 hasConcept C2776878037 @default.
• W2613273453 hasConcept C2778004101 @default.
• W2613273453 hasConcept C2779719074 @default.
• W2613273453 hasConcept C2780269544 @default.
• W2613273453 hasConcept C2780416994 @default.
• W2613273453 hasConcept C48349386 @default.
• W2613273453 hasConcept C533411734 @default.
• W2613273453 hasConcept C54166955 @default.
• W2613273453 hasConcept C55493867 @default.
• W2613273453 hasConcept C86803240 @default.
• W2613273453 hasConcept C95444343 @default.
• W2613273453 hasConceptScore W2613273453C104317684 @default.
• W2613273453 hasConceptScore W2613273453C12554922 @default.
• W2613273453 hasConceptScore W2613273453C162008176 @default.
• W2613273453 hasConceptScore W2613273453C170493617 @default.
• W2613273453 hasConceptScore W2613273453C181199279 @default.
• W2613273453 hasConceptScore W2613273453C185592680 @default.
• W2613273453 hasConceptScore W2613273453C203014093 @default.
• W2613273453 hasConceptScore W2613273453C2776878037 @default.
• W2613273453 hasConceptScore W2613273453C2778004101 @default.
• W2613273453 hasConceptScore W2613273453C2779719074 @default.
• W2613273453 hasConceptScore W2613273453C2780269544 @default.
• W2613273453 hasConceptScore W2613273453C2780416994 @default.
• W2613273453 hasConceptScore W2613273453C48349386 @default.
• W2613273453 hasConceptScore W2613273453C533411734 @default.
• W2613273453 hasConceptScore W2613273453C54166955 @default.
• W2613273453 hasConceptScore W2613273453C55493867 @default.
• W2613273453 hasConceptScore W2613273453C86803240 @default.
• W2613273453 hasConceptScore W2613273453C95444343 @default.

• next