FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2613331751> ?p ?o ?g. }

• W2613331751 abstract "A 44-year-old woman with a prior history of myxoid liposarcoma who was previously treated with radiation, chemotherapy, and resection, was admitted with syncope and pancytopenia. She was diagnosed with a high-grade therapy-related myelodysplastic syndrome and treated with decitabine. Her disease soon progressed to overt acute myeloid leukemia (AML). She was treated with cytotoxic chemotherapy including cytarabine and topotecan, but she was not a candidate for further anthracycline exposure given her prior treatment for sarcoma and concern for cardiotoxicity. Her AML was refractory to two sequential induction regimens. Given that targeted genomic sequencing had revealed a BRAF V600E mutation with a high allelic fraction, she was then placed on combined targeted BRAF/MEK therapy with dabrafenib and trametinib for her refractory disease. This resulted in a dramatic response with clearance of circulating myeloblasts, restoration of normal hematopoiesis, a significant decrease in marrow leukemic burden, and a concordant decrease in the BRAF V600E allelic burden. The response was transient, however, with a rapid increase in circulating blasts a few weeks later. At the time of subsequent progression, four separate KRAS mutations were identified. She died approximately 4 months after her diagnosis from rapidly progressive AML." @default.
• W2613331751 created "2017-05-19" @default.
• W2613331751 creator A5005865384 @default.
• W2613331751 creator A5009387581 @default.
• W2613331751 creator A5010057352 @default.
• W2613331751 creator A5025351031 @default.
• W2613331751 creator A5028418409 @default.
• W2613331751 creator A5033769845 @default.
• W2613331751 creator A5037732121 @default.
• W2613331751 creator A5047327236 @default.
• W2613331751 creator A5056921013 @default.
• W2613331751 creator A5078592778 @default.
• W2613331751 date "2017-11-01" @default.
• W2613331751 modified "2023-09-27" @default.
• W2613331751 title "Combined Targeted Therapy for BRAF-Mutant, Treatment-Related Acute Myeloid Leukemia" @default.
• W2613331751 cites W1255676896 @default.
• W2613331751 cites W1441792155 @default.
• W2613331751 cites W1965370740 @default.
• W2613331751 cites W1978653625 @default.
• W2613331751 cites W1980852206 @default.
• W2613331751 cites W1982443780 @default.
• W2613331751 cites W1985821753 @default.
• W2613331751 cites W1990011632 @default.
• W2613331751 cites W2003402062 @default.
• W2613331751 cites W2009642188 @default.
• W2613331751 cites W2012753533 @default.
• W2613331751 cites W2014250484 @default.
• W2613331751 cites W2014881369 @default.
• W2613331751 cites W2018240559 @default.
• W2613331751 cites W2032211985 @default.
• W2613331751 cites W2053122879 @default.
• W2613331751 cites W2083435672 @default.
• W2613331751 cites W2099780734 @default.
• W2613331751 cites W2100614336 @default.
• W2613331751 cites W2103557568 @default.
• W2613331751 cites W2110682589 @default.
• W2613331751 cites W2120437980 @default.
• W2613331751 cites W2130930297 @default.
• W2613331751 cites W2131040858 @default.
• W2613331751 cites W2134061682 @default.
• W2613331751 cites W2141787711 @default.
• W2613331751 cites W2157783208 @default.
• W2613331751 cites W2163188200 @default.
• W2613331751 cites W2163895976 @default.
• W2613331751 cites W2254594392 @default.
• W2613331751 cites W2311815386 @default.
• W2613331751 cites W2344901527 @default.
• W2613331751 cites W2419140434 @default.
• W2613331751 doi "https://doi.org/10.1200/po.16.00032" @default.
• W2613331751 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35172484" @default.
• W2613331751 hasPublicationYear "2017" @default.
• W2613331751 type Work @default.
• W2613331751 sameAs 2613331751 @default.
• W2613331751 citedByCount "3" @default.
• W2613331751 countsByYear W26133317512018 @default.
• W2613331751 countsByYear W26133317512020 @default.
• W2613331751 crossrefType "journal-article" @default.
• W2613331751 hasAuthorship W2613331751A5005865384 @default.
• W2613331751 hasAuthorship W2613331751A5009387581 @default.
• W2613331751 hasAuthorship W2613331751A5010057352 @default.
• W2613331751 hasAuthorship W2613331751A5025351031 @default.
• W2613331751 hasAuthorship W2613331751A5028418409 @default.
• W2613331751 hasAuthorship W2613331751A5033769845 @default.
• W2613331751 hasAuthorship W2613331751A5037732121 @default.
• W2613331751 hasAuthorship W2613331751A5047327236 @default.
• W2613331751 hasAuthorship W2613331751A5056921013 @default.
• W2613331751 hasAuthorship W2613331751A5078592778 @default.
• W2613331751 hasConcept C121608353 @default.
• W2613331751 hasConcept C126322002 @default.
• W2613331751 hasConcept C143998085 @default.
• W2613331751 hasConcept C184235292 @default.
• W2613331751 hasConcept C2778019345 @default.
• W2613331751 hasConcept C2778041864 @default.
• W2613331751 hasConcept C2778461978 @default.
• W2613331751 hasConcept C2778472372 @default.
• W2613331751 hasConcept C2778695046 @default.
• W2613331751 hasConcept C2778729363 @default.
• W2613331751 hasConcept C2779382419 @default.
• W2613331751 hasConcept C2780007613 @default.
• W2613331751 hasConcept C2781230642 @default.
• W2613331751 hasConcept C502942594 @default.
• W2613331751 hasConcept C57074206 @default.
• W2613331751 hasConcept C71924100 @default.
• W2613331751 hasConcept C86803240 @default.
• W2613331751 hasConcept C95444343 @default.
• W2613331751 hasConceptScore W2613331751C121608353 @default.
• W2613331751 hasConceptScore W2613331751C126322002 @default.
• W2613331751 hasConceptScore W2613331751C143998085 @default.
• W2613331751 hasConceptScore W2613331751C184235292 @default.
• W2613331751 hasConceptScore W2613331751C2778019345 @default.
• W2613331751 hasConceptScore W2613331751C2778041864 @default.
• W2613331751 hasConceptScore W2613331751C2778461978 @default.
• W2613331751 hasConceptScore W2613331751C2778472372 @default.
• W2613331751 hasConceptScore W2613331751C2778695046 @default.
• W2613331751 hasConceptScore W2613331751C2778729363 @default.
• W2613331751 hasConceptScore W2613331751C2779382419 @default.
• W2613331751 hasConceptScore W2613331751C2780007613 @default.
• W2613331751 hasConceptScore W2613331751C2781230642 @default.
• W2613331751 hasConceptScore W2613331751C502942594 @default.
• W2613331751 hasConceptScore W2613331751C57074206 @default.

• next