FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2613418607> ?p ?o ?g. }

• W2613418607 abstract "Cancer is a heterogeneous disease, thus one of the central problems is how to dissect the resulting complex phenotypes in terms of their biological building blocks. Computationally, this is to represent and interpret high dimensional observations through a structural and conceptual abstraction into the most influential determinants underlying the problem. The working hypothesis of this report is to consider gene interaction to be largely responsible for the manifestation of complex cancer phenotypes, thus where the representation is to be conceptualized. Here, we report a representation learning strategy combined with regularizations, in which gene expressions are described in terms of a regularized product of meta-genes and their expression levels. The meta-genes are constrained by gene interactions thus representing their original topological contexts. The expression levels are supervised by their conditional dependencies among the observations thus providing a cluster-specific constraint. We obtain both of these structural constraints using a node-based graphical model. Our representation allows the selection of more influential modules, thus implicating their possible roles in neoplastic transformations. We validate our representation strategy by its robust recognitions of various cancer phenotypes comparing with various classical methods. The modules discovered are either shared or specify for different types or stages of human cancers, all of which are consistent with literature and biology." @default.
• W2613418607 created "2017-05-19" @default.
• W2613418607 creator A5001717730 @default.
• W2613418607 creator A5003333805 @default.
• W2613418607 creator A5060107207 @default.
• W2613418607 creator A5083854815 @default.
• W2613418607 date "2019-09-01" @default.
• W2613418607 modified "2023-10-16" @default.
• W2613418607 title "Learning a Structural and Functional Representation for Gene Expressions: To Systematically Dissect Complex Cancer Phenotypes" @default.
• W2613418607 cites W1012752328 @default.
• W2613418607 cites W1503398984 @default.
• W2613418607 cites W1543476772 @default.
• W2613418607 cites W1544851750 @default.
• W2613418607 cites W1893900968 @default.
• W2613418607 cites W1902027874 @default.
• W2613418607 cites W1968580628 @default.
• W2613418607 cites W1969706233 @default.
• W2613418607 cites W1974625077 @default.
• W2613418607 cites W1974673111 @default.
• W2613418607 cites W1979260070 @default.
• W2613418607 cites W1985054565 @default.
• W2613418607 cites W1994251758 @default.
• W2613418607 cites W1994778124 @default.
• W2613418607 cites W2005071155 @default.
• W2613418607 cites W2006520400 @default.
• W2613418607 cites W2007950075 @default.
• W2613418607 cites W2013544810 @default.
• W2613418607 cites W2023997192 @default.
• W2613418607 cites W2032864009 @default.
• W2613418607 cites W2033026851 @default.
• W2613418607 cites W2033505501 @default.
• W2613418607 cites W2062393124 @default.
• W2613418607 cites W2068036075 @default.
• W2613418607 cites W2071765634 @default.
• W2613418607 cites W2077358581 @default.
• W2613418607 cites W2087039607 @default.
• W2613418607 cites W2089307978 @default.
• W2613418607 cites W2097413644 @default.
• W2613418607 cites W2099041486 @default.
• W2613418607 cites W2108119513 @default.
• W2613418607 cites W2108722802 @default.
• W2613418607 cites W2109363337 @default.
• W2613418607 cites W2109761160 @default.
• W2613418607 cites W2116063398 @default.
• W2613418607 cites W2118037512 @default.
• W2613418607 cites W2118124054 @default.
• W2613418607 cites W2119727971 @default.
• W2613418607 cites W2126097399 @default.
• W2613418607 cites W2128728535 @default.
• W2613418607 cites W2128728700 @default.
• W2613418607 cites W2130854041 @default.
• W2613418607 cites W2132692097 @default.
• W2613418607 cites W2135160607 @default.
• W2613418607 cites W2136787567 @default.
• W2613418607 cites W2137823674 @default.
• W2613418607 cites W2140266186 @default.
• W2613418607 cites W2140318696 @default.
• W2613418607 cites W2141444430 @default.
• W2613418607 cites W2142980147 @default.
• W2613418607 cites W2143350625 @default.
• W2613418607 cites W2151646205 @default.
• W2613418607 cites W2153398041 @default.
• W2613418607 cites W2154951934 @default.
• W2613418607 cites W2155151262 @default.
• W2613418607 cites W2162215411 @default.
• W2613418607 cites W2164616133 @default.
• W2613418607 cites W2164786997 @default.
• W2613418607 cites W2165685007 @default.
• W2613418607 cites W2166098345 @default.
• W2613418607 cites W2170656321 @default.
• W2613418607 cites W2319832910 @default.
• W2613418607 cites W2106895029 @default.
• W2613418607 doi "https://doi.org/10.1109/tcbb.2017.2702161" @default.
• W2613418607 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28489545" @default.
• W2613418607 hasPublicationYear "2019" @default.
• W2613418607 type Work @default.
• W2613418607 sameAs 2613418607 @default.
• W2613418607 citedByCount "1" @default.
• W2613418607 countsByYear W26134186072019 @default.
• W2613418607 crossrefType "journal-article" @default.
• W2613418607 hasAuthorship W2613418607A5001717730 @default.
• W2613418607 hasAuthorship W2613418607A5003333805 @default.
• W2613418607 hasAuthorship W2613418607A5060107207 @default.
• W2613418607 hasAuthorship W2613418607A5083854815 @default.
• W2613418607 hasConcept C104317684 @default.
• W2613418607 hasConcept C111472728 @default.
• W2613418607 hasConcept C124304363 @default.
• W2613418607 hasConcept C127716648 @default.
• W2613418607 hasConcept C138885662 @default.
• W2613418607 hasConcept C152662350 @default.
• W2613418607 hasConcept C154945302 @default.
• W2613418607 hasConcept C17744445 @default.
• W2613418607 hasConcept C199360897 @default.
• W2613418607 hasConcept C199539241 @default.
• W2613418607 hasConcept C2524010 @default.
• W2613418607 hasConcept C2776036281 @default.
• W2613418607 hasConcept C2776359362 @default.
• W2613418607 hasConcept C33923547 @default.
• W2613418607 hasConcept C41008148 @default.
• W2613418607 hasConcept C54355233 @default.

• next