FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2613422421> ?p ?o ?g. }

• W2613422421 endingPage "1756" @default.
• W2613422421 startingPage "1749" @default.
• W2613422421 abstract "Cutaneous melanoma (CM) is the most lethal skin cancer. The Wnt pathway has an impact on development, invasion, and metastasis of CM, thus likely affecting CM prognosis. Using data from a published genome-wide association study from The University of Texas MD Anderson Cancer Center, we assessed the associations of 19,830 common single-nucleotide polymorphisms (SNPs) in 151 Wnt pathway autosomal genes with CM-specific survival and then validated significant SNPs in another genome-wide association study from Harvard University. In the single-locus analysis, 1,855 SNPs were significantly associated with CM-specific survival at P < 0.05, of which 547 SNPs were still considered noteworthy after the correction by the false-positive report probability. In the replication, two SNPs remained significantly associated with CM-specific survival after multiple comparison correction. By performing functional prediction and stepwise selection, we identified two independent SNPs (i.e., WNT2B rs1175649 G>T and BTRC rs61873997 G>A) that showed a predictive role in CM-specific survival, with an effect-allele-attributed hazards ratio (adjusted hazards ratio) of 1.99 (95% confidence interval = 1.41-2.81, P = 8.10 × 10-5) and 0.61 (0.46-0.80, 3.12×10-4), respectively. Collectively, these variants in the Wnt pathway genes may be biomarkers for outcomes of patients with CM, if validated by larger studies." @default.
• W2613422421 created "2017-05-19" @default.
• W2613422421 creator A5012210223 @default.
• W2613422421 creator A5017443210 @default.
• W2613422421 creator A5021831026 @default.
• W2613422421 creator A5022491856 @default.
• W2613422421 creator A5022539949 @default.
• W2613422421 creator A5023006263 @default.
• W2613422421 creator A5023633716 @default.
• W2613422421 creator A5028989565 @default.
• W2613422421 creator A5031168277 @default.
• W2613422421 creator A5033941158 @default.
• W2613422421 creator A5054850370 @default.
• W2613422421 creator A5084811923 @default.
• W2613422421 date "2017-08-01" @default.
• W2613422421 modified "2023-09-25" @default.
• W2613422421 title "Genetic Variants in WNT2B and BTRC Predict Melanoma Survival" @default.
• W2613422421 cites W1567260411 @default.
• W2613422421 cites W1958993671 @default.
• W2613422421 cites W1975918891 @default.
• W2613422421 cites W1978019253 @default.
• W2613422421 cites W1990563353 @default.
• W2613422421 cites W1998790582 @default.
• W2613422421 cites W1999146832 @default.
• W2613422421 cites W2006419043 @default.
• W2613422421 cites W2009434058 @default.
• W2613422421 cites W2013810503 @default.
• W2613422421 cites W2017758716 @default.
• W2613422421 cites W2018838463 @default.
• W2613422421 cites W2025943989 @default.
• W2613422421 cites W2033032651 @default.
• W2613422421 cites W2039663696 @default.
• W2613422421 cites W2043691868 @default.
• W2613422421 cites W2050839565 @default.
• W2613422421 cites W2063109569 @default.
• W2613422421 cites W2067823229 @default.
• W2613422421 cites W2073924618 @default.
• W2613422421 cites W2075225790 @default.
• W2613422421 cites W2083571191 @default.
• W2613422421 cites W2091014158 @default.
• W2613422421 cites W2096791516 @default.
• W2613422421 cites W2097051847 @default.
• W2613422421 cites W2101683587 @default.
• W2613422421 cites W2104877706 @default.
• W2613422421 cites W2118705337 @default.
• W2613422421 cites W2118863192 @default.
• W2613422421 cites W2120488402 @default.
• W2613422421 cites W2134936717 @default.
• W2613422421 cites W2139544397 @default.
• W2613422421 cites W2145439424 @default.
• W2613422421 cites W2146167376 @default.
• W2613422421 cites W2150486170 @default.
• W2613422421 cites W2151576670 @default.
• W2613422421 cites W2154554327 @default.
• W2613422421 cites W2157873170 @default.
• W2613422421 cites W2159969192 @default.
• W2613422421 cites W2165685789 @default.
• W2613422421 cites W2166501262 @default.
• W2613422421 cites W2169468059 @default.
• W2613422421 cites W2202471480 @default.
• W2613422421 cites W2235523093 @default.
• W2613422421 cites W2333491752 @default.
• W2613422421 doi "https://doi.org/10.1016/j.jid.2017.04.023" @default.
• W2613422421 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5548422" @default.
• W2613422421 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28499756" @default.
• W2613422421 hasPublicationYear "2017" @default.
• W2613422421 type Work @default.
• W2613422421 sameAs 2613422421 @default.
• W2613422421 citedByCount "5" @default.
• W2613422421 countsByYear W26134224212019 @default.
• W2613422421 countsByYear W26134224212020 @default.
• W2613422421 countsByYear W26134224212021 @default.
• W2613422421 crossrefType "journal-article" @default.
• W2613422421 hasAuthorship W2613422421A5012210223 @default.
• W2613422421 hasAuthorship W2613422421A5017443210 @default.
• W2613422421 hasAuthorship W2613422421A5021831026 @default.
• W2613422421 hasAuthorship W2613422421A5022491856 @default.
• W2613422421 hasAuthorship W2613422421A5022539949 @default.
• W2613422421 hasAuthorship W2613422421A5023006263 @default.
• W2613422421 hasAuthorship W2613422421A5023633716 @default.
• W2613422421 hasAuthorship W2613422421A5028989565 @default.
• W2613422421 hasAuthorship W2613422421A5031168277 @default.
• W2613422421 hasAuthorship W2613422421A5033941158 @default.
• W2613422421 hasAuthorship W2613422421A5054850370 @default.
• W2613422421 hasAuthorship W2613422421A5084811923 @default.
• W2613422421 hasBestOaLocation W26134224211 @default.
• W2613422421 hasConcept C104317684 @default.
• W2613422421 hasConcept C10515644 @default.
• W2613422421 hasConcept C106208931 @default.
• W2613422421 hasConcept C126322002 @default.
• W2613422421 hasConcept C135763542 @default.
• W2613422421 hasConcept C137620995 @default.
• W2613422421 hasConcept C143998085 @default.
• W2613422421 hasConcept C153209595 @default.
• W2613422421 hasConcept C180754005 @default.
• W2613422421 hasConcept C44249647 @default.
• W2613422421 hasConcept C50382708 @default.
• W2613422421 hasConcept C54355233 @default.

• next