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- W2613457895 abstract "To investigate the distribution of cystathionine-beta-synthase (CBS) in the brain of the spontaneous hypertensive rat. Eight adult male spontaneously hypertensive rats (SHR), and 8 pargue-Darley (SD) rats were assigned into hypertensive group and control group correspondingly. All rats were killed by over-dose anesthesia. The cerebral cortex, cerebellum, hypothalamus, hippocampus, medulla oblongata were dissociated quickly. Their mRNA of CBS was detected by RT-PCR or Real Time-PCR. The transcriptional levels of CBS in brains in the SHR group were significantly decrease compared with the normal control group (0.93 ± 0.01 vs. 1.00 ± 0.00, P<0.05; 0.39 ± 0.02 vs. 1.00 ± 0.00, P<0.01; 0.07 ± 0.01 vs. 1.00 ± 0.00, P<0.01; 0.09 ± 0.03 vs. 1.00 ± 0.00, P<0.01; 0.36 ± 0.06 vs. 1.00 ± 0.00, P<0.01). The expression of CBS mRNA in brain tissue of SHR rats are down-regulated, it is likely to get through the mechanism of central, such as medulla oblongata, which probably involved in the pathogenesis of hypertension." @default.
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- W2613457895 date "2014-05-01" @default.
- W2613457895 modified "2023-09-27" @default.
- W2613457895 title "P57" @default.
- W2613457895 doi "https://doi.org/10.1016/j.niox.2014.03.107" @default.
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