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- W2613503805 endingPage "e0176937" @default.
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- W2613503805 abstract "β-Lapachone is a natural quinone compound from Lapacho trees, which has various pharmacological effects such as anti-bacterial, anti-fungal, anti-viral, and anti-inflammatory activities. However, the effect of β-lapachone on metastasis of melanoma cells is unclear. In this study, β-lapachone reduced cell viability of metastatic melanoma cancer cell lines B16F10 and B16BL6 through induction of apoptosis via the mitogen-activated protein kinase (MAPK) pathway. Additionally, flow cytometry results showed that β-lapachone increased DNA content in the G0/G1 phase of the cell cycle. Analysis of the mechanisms of these events indicated that β-lapachone regulated the expression of Bcl-2, Bcl-xL, and Bax, resulting in the activation of caspase-3, -8, -9, and poly-ADP-ribose polymerase (PARP). Moreover, the β-lapachone-administered group showed significantly decreased lung metastasis in the experimental mouse model. In conclusion, our study demonstrates the inhibitory effect of β-lapachone on lung metastasis of melanoma cells and provides a new insight into the role of β-lapachone as a potential antitumor agent." @default.
- W2613503805 created "2017-05-19" @default.
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- W2613503805 date "2017-05-08" @default.
- W2613503805 modified "2023-10-17" @default.
- W2613503805 title "β-Lapachone suppresses the lung metastasis of melanoma via the MAPK signaling pathway" @default.
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- W2613503805 doi "https://doi.org/10.1371/journal.pone.0176937" @default.
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