Matches in SemOpenAlex for { <https://semopenalex.org/work/W2613564777> ?p ?o ?g. }
- W2613564777 endingPage "163" @default.
- W2613564777 startingPage "163" @default.
- W2613564777 abstract "Animal-derived antivenoms constitute the mainstay in the therapy of snakebite envenoming. The efficacy of antivenoms to neutralize toxicity of medically-relevant snake venoms has to be demonstrated through meticulous preclinical testing before their introduction into the clinical setting. The gold standard in the preclinical assessment and quality control of antivenoms is the neutralization of venom-induced lethality. In addition, depending on the pathophysiological profile of snake venoms, the neutralization of other toxic activities has to be evaluated, such as hemorrhagic, myotoxic, edema-forming, dermonecrotic, in vitro coagulant, and defibrinogenating effects. There is a need to develop laboratory assays to evaluate neutralization of other relevant venom activities. The concept of the 3Rs (Replacement, Reduction, and Refinement) in Toxinology is of utmost importance, and some advances have been performed in their implementation. A significant leap forward in the study of the immunological reactivity of antivenoms against venoms has been the development of “antivenomics”, which brings the analytical power of mass spectrometry to the evaluation of antivenoms. International partnerships are required to assess the preclinical efficacy of antivenoms against snake venoms in different regions of the world in order to have a detailed knowledge on the neutralizing profile of these immunotherapeutics." @default.
- W2613564777 created "2017-05-19" @default.
- W2613564777 creator A5003513067 @default.
- W2613564777 creator A5003831080 @default.
- W2613564777 creator A5006918687 @default.
- W2613564777 creator A5031739200 @default.
- W2613564777 creator A5033074190 @default.
- W2613564777 creator A5042977345 @default.
- W2613564777 creator A5055816232 @default.
- W2613564777 creator A5055824372 @default.
- W2613564777 creator A5063475199 @default.
- W2613564777 creator A5077807874 @default.
- W2613564777 creator A5079027751 @default.
- W2613564777 creator A5081481260 @default.
- W2613564777 date "2017-05-13" @default.
- W2613564777 modified "2023-10-16" @default.
- W2613564777 title "Preclinical Evaluation of the Efficacy of Antivenoms for Snakebite Envenoming: State-of-the-Art and Challenges Ahead" @default.
- W2613564777 cites W1642031822 @default.
- W2613564777 cites W1840613833 @default.
- W2613564777 cites W1842209614 @default.
- W2613564777 cites W1867204799 @default.
- W2613564777 cites W1965190825 @default.
- W2613564777 cites W1966869866 @default.
- W2613564777 cites W1966881658 @default.
- W2613564777 cites W1968876368 @default.
- W2613564777 cites W1969265645 @default.
- W2613564777 cites W1970927146 @default.
- W2613564777 cites W1972130976 @default.
- W2613564777 cites W1972294137 @default.
- W2613564777 cites W1976813733 @default.
- W2613564777 cites W1980387413 @default.
- W2613564777 cites W1980482622 @default.
- W2613564777 cites W1981395064 @default.
- W2613564777 cites W1983820236 @default.
- W2613564777 cites W1985732380 @default.
- W2613564777 cites W1985981054 @default.
- W2613564777 cites W1986736895 @default.
- W2613564777 cites W1988014775 @default.
- W2613564777 cites W1988567937 @default.
- W2613564777 cites W1989785549 @default.
- W2613564777 cites W1991690347 @default.
- W2613564777 cites W1992983011 @default.
- W2613564777 cites W1994965374 @default.
- W2613564777 cites W1995571414 @default.
- W2613564777 cites W1995833375 @default.
- W2613564777 cites W1996742946 @default.
- W2613564777 cites W1999376351 @default.
- W2613564777 cites W1999774962 @default.
- W2613564777 cites W2001670682 @default.
- W2613564777 cites W2003557975 @default.
- W2613564777 cites W2006124737 @default.
- W2613564777 cites W2007515291 @default.
- W2613564777 cites W2007714227 @default.
- W2613564777 cites W2007955614 @default.
- W2613564777 cites W2008257463 @default.
- W2613564777 cites W2008964357 @default.
- W2613564777 cites W2010012196 @default.
- W2613564777 cites W2010111273 @default.
- W2613564777 cites W2013238756 @default.
- W2613564777 cites W2013622729 @default.
- W2613564777 cites W2014928855 @default.
- W2613564777 cites W2015349300 @default.
- W2613564777 cites W2015718953 @default.
- W2613564777 cites W2016008242 @default.
- W2613564777 cites W2016764522 @default.
- W2613564777 cites W2017237521 @default.
- W2613564777 cites W2018393723 @default.
- W2613564777 cites W2018897047 @default.
- W2613564777 cites W2020924218 @default.
- W2613564777 cites W2021770894 @default.
- W2613564777 cites W2021931204 @default.
- W2613564777 cites W2023592738 @default.
- W2613564777 cites W2025650668 @default.
- W2613564777 cites W2028285527 @default.
- W2613564777 cites W2029136951 @default.
- W2613564777 cites W2029604585 @default.
- W2613564777 cites W2030190455 @default.
- W2613564777 cites W2032035391 @default.
- W2613564777 cites W2037085760 @default.
- W2613564777 cites W2037439512 @default.
- W2613564777 cites W2037577074 @default.
- W2613564777 cites W2037717176 @default.
- W2613564777 cites W2042580288 @default.
- W2613564777 cites W2044140319 @default.
- W2613564777 cites W2048849328 @default.
- W2613564777 cites W2049346218 @default.
- W2613564777 cites W2049980314 @default.
- W2613564777 cites W2051583331 @default.
- W2613564777 cites W2055170446 @default.
- W2613564777 cites W2055718795 @default.
- W2613564777 cites W2061565150 @default.
- W2613564777 cites W2064991393 @default.
- W2613564777 cites W2066665780 @default.
- W2613564777 cites W2069816601 @default.
- W2613564777 cites W2069882002 @default.
- W2613564777 cites W2072810823 @default.
- W2613564777 cites W2075826307 @default.
- W2613564777 cites W2075857130 @default.