Matches in SemOpenAlex for { <https://semopenalex.org/work/W261357574> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W261357574 abstract "In addition to its contractile role, Ca ++ may also serve as an important messenger in coordinating the rate of substrate catabolism and mechanical energy expenditure. The sources/pools usually considered to play a dominate role in providing contractile Ca ++ are the slow inward current, sarcolemmal Na + –Ca ++ exchange, and the sarcoplasmic reticulum. Data from previous studies indicate that the slow inward current may augment the Ca ++ associated with coordinating the rate of catabolism with mechanical power and that Na + – Ca ++ - exchange does not appreciably contribute. This chapter presents the results of studies in which theophylline (THEO) was used to affect mobilization of sarcoplasmic reticulum Ca ++ . The data show that THEO significantly increases the sensitivity of the major catabolic pathways to changes in contractile power. The effect of this change was to greatly decrease the extent of oxidation of the respiratory chain (RC) accompanying an increase in power expenditure or, especially with glucose, actually produce a reduction. In the study, experiments were performed on isometrically mounted rabbit papillary muscles immersed in Ringer solution. The redox state of the RC was noninvasively monitored by measuring the mitochondrial pyridine nucleotide (PN) fluorescence. As is evident, the presence of THEO reduced the developed tension and significantly decreased the extent of P MX . With 10 mM THEO, P MX was negative indicating that a reduction of PN and the RC accompanied the onset of contractile activity. The cumulative results show that THEO marginally affects mechanical performance. At 5 and 10 mM THEO, the extent of PN oxidation accompanying an increase in contractile performance was significantly decreased particularly with glucose or butyric acid as the substrate." @default.
- W261357574 created "2016-06-24" @default.
- W261357574 creator A5026971849 @default.
- W261357574 date "1981-01-01" @default.
- W261357574 modified "2023-09-27" @default.
- W261357574 title "THEOPHYLLINE INDUCED CHANGES OF RESPIRATORY CHAIN FUNCTION IN RABBIT PAPILLARY MUSCLE" @default.
- W261357574 cites W1595626863 @default.
- W261357574 cites W1995272538 @default.
- W261357574 cites W2039492201 @default.
- W261357574 cites W2134274931 @default.
- W261357574 cites W2138151365 @default.
- W261357574 doi "https://doi.org/10.1016/b978-0-08-027346-4.50026-7" @default.
- W261357574 hasPublicationYear "1981" @default.
- W261357574 type Work @default.
- W261357574 sameAs 261357574 @default.
- W261357574 citedByCount "0" @default.
- W261357574 crossrefType "book-chapter" @default.
- W261357574 hasAuthorship W261357574A5026971849 @default.
- W261357574 hasConcept C12554922 @default.
- W261357574 hasConcept C126322002 @default.
- W261357574 hasConcept C134018914 @default.
- W261357574 hasConcept C158617107 @default.
- W261357574 hasConcept C181199279 @default.
- W261357574 hasConcept C185592680 @default.
- W261357574 hasConcept C2778095195 @default.
- W261357574 hasConcept C3020377403 @default.
- W261357574 hasConcept C534529494 @default.
- W261357574 hasConcept C55493867 @default.
- W261357574 hasConcept C62231903 @default.
- W261357574 hasConcept C71924100 @default.
- W261357574 hasConcept C86803240 @default.
- W261357574 hasConcept C96942376 @default.
- W261357574 hasConceptScore W261357574C12554922 @default.
- W261357574 hasConceptScore W261357574C126322002 @default.
- W261357574 hasConceptScore W261357574C134018914 @default.
- W261357574 hasConceptScore W261357574C158617107 @default.
- W261357574 hasConceptScore W261357574C181199279 @default.
- W261357574 hasConceptScore W261357574C185592680 @default.
- W261357574 hasConceptScore W261357574C2778095195 @default.
- W261357574 hasConceptScore W261357574C3020377403 @default.
- W261357574 hasConceptScore W261357574C534529494 @default.
- W261357574 hasConceptScore W261357574C55493867 @default.
- W261357574 hasConceptScore W261357574C62231903 @default.
- W261357574 hasConceptScore W261357574C71924100 @default.
- W261357574 hasConceptScore W261357574C86803240 @default.
- W261357574 hasConceptScore W261357574C96942376 @default.
- W261357574 hasLocation W2613575741 @default.
- W261357574 hasOpenAccess W261357574 @default.
- W261357574 hasPrimaryLocation W2613575741 @default.
- W261357574 hasRelatedWork W1511189929 @default.
- W261357574 hasRelatedWork W1963715479 @default.
- W261357574 hasRelatedWork W2060986807 @default.
- W261357574 hasRelatedWork W2070523542 @default.
- W261357574 hasRelatedWork W2079737258 @default.
- W261357574 hasRelatedWork W2083250779 @default.
- W261357574 hasRelatedWork W2118137246 @default.
- W261357574 hasRelatedWork W2138487576 @default.
- W261357574 hasRelatedWork W2318689028 @default.
- W261357574 hasRelatedWork W2323919468 @default.
- W261357574 hasRelatedWork W2334267925 @default.
- W261357574 hasRelatedWork W2336187711 @default.
- W261357574 hasRelatedWork W2402126518 @default.
- W261357574 hasRelatedWork W2411124210 @default.
- W261357574 hasRelatedWork W2418057216 @default.
- W261357574 hasRelatedWork W2437024180 @default.
- W261357574 hasRelatedWork W2790920508 @default.
- W261357574 hasRelatedWork W3148132283 @default.
- W261357574 hasRelatedWork W2182129357 @default.
- W261357574 hasRelatedWork W2604844503 @default.
- W261357574 isParatext "false" @default.
- W261357574 isRetracted "false" @default.
- W261357574 magId "261357574" @default.
- W261357574 workType "book-chapter" @default.