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- W2613597569 endingPage "1768" @default.
- W2613597569 startingPage "1755" @default.
- W2613597569 abstract "The RUNX1 transcription factor is a critical regulator of normal haematopoiesis and its functional disruption by point mutations, deletions or translocations is a major causative factor leading to leukaemia. In the majority of cases, genetic changes in RUNX1 are linked to loss of function classifying it broadly as a tumour suppressor. Despite this, several recent studies have reported the need for a certain level of active RUNX1 for the maintenance and propagation of acute myeloid leukaemia and acute lymphoblastic leukaemia cells, suggesting an oncosupportive role of RUNX1. Furthermore, in solid cancers, RUNX1 is overexpressed compared with normal tissue, and RUNX factors have recently been discovered to promote growth of skin, oral, breast and ovarian tumour cells, amongst others. RUNX factors have key roles in stem cell fate regulation during homeostasis and regeneration of many tissues. Cancer cells appear to have corrupted these stem cell-associated functions of RUNX factors to promote oncogenesis. Here, we discuss current knowledge on the role of RUNX genes in stem cells and as oncosupportive factors in haematological malignancies and epithelial cancers." @default.
- W2613597569 created "2017-05-19" @default.
- W2613597569 creator A5013798687 @default.
- W2613597569 creator A5078620092 @default.
- W2613597569 date "2017-05-10" @default.
- W2613597569 modified "2023-10-03" @default.
- W2613597569 title "RUNX transcription factors at the interface of stem cells and cancer" @default.
- W2613597569 cites W1512755592 @default.
- W2613597569 cites W15248648 @default.
- W2613597569 cites W1538540497 @default.
- W2613597569 cites W1586675360 @default.
- W2613597569 cites W1736968472 @default.
- W2613597569 cites W1739103212 @default.
- W2613597569 cites W1848800158 @default.
- W2613597569 cites W1861200333 @default.
- W2613597569 cites W1934471843 @default.
- W2613597569 cites W1954676808 @default.
- W2613597569 cites W1969375089 @default.
- W2613597569 cites W1973592216 @default.
- W2613597569 cites W1974000482 @default.
- W2613597569 cites W1982721874 @default.
- W2613597569 cites W1984633396 @default.
- W2613597569 cites W1985567721 @default.
- W2613597569 cites W1991640996 @default.
- W2613597569 cites W1991766825 @default.
- W2613597569 cites W1991868953 @default.
- W2613597569 cites W1997487188 @default.
- W2613597569 cites W2007598335 @default.
- W2613597569 cites W2008018118 @default.
- W2613597569 cites W2008102732 @default.
- W2613597569 cites W2009307227 @default.
- W2613597569 cites W2011033296 @default.
- W2613597569 cites W2025545218 @default.
- W2613597569 cites W2035543326 @default.
- W2613597569 cites W2036912911 @default.
- W2613597569 cites W2039655485 @default.
- W2613597569 cites W2041808159 @default.
- W2613597569 cites W2044740110 @default.
- W2613597569 cites W2046882508 @default.
- W2613597569 cites W2053603023 @default.
- W2613597569 cites W2055768277 @default.
- W2613597569 cites W2055922911 @default.
- W2613597569 cites W2056446394 @default.
- W2613597569 cites W2057380923 @default.
- W2613597569 cites W2058998284 @default.
- W2613597569 cites W2060580006 @default.
- W2613597569 cites W2063170763 @default.
- W2613597569 cites W2067786908 @default.
- W2613597569 cites W2074645605 @default.
- W2613597569 cites W2076428533 @default.
- W2613597569 cites W2080607444 @default.
- W2613597569 cites W2082887122 @default.
- W2613597569 cites W2083575840 @default.
- W2613597569 cites W2085033687 @default.
- W2613597569 cites W2091814813 @default.
- W2613597569 cites W2091929662 @default.
- W2613597569 cites W2092194090 @default.
- W2613597569 cites W2093588238 @default.
- W2613597569 cites W2094547160 @default.
- W2613597569 cites W2094601641 @default.
- W2613597569 cites W2096283457 @default.
- W2613597569 cites W2098049369 @default.
- W2613597569 cites W2101518963 @default.
- W2613597569 cites W2103012849 @default.
- W2613597569 cites W2103866717 @default.
- W2613597569 cites W2107753978 @default.
- W2613597569 cites W2110918588 @default.
- W2613597569 cites W2115588415 @default.
- W2613597569 cites W2118717300 @default.
- W2613597569 cites W2119851259 @default.
- W2613597569 cites W2128741634 @default.
- W2613597569 cites W2134281532 @default.
- W2613597569 cites W2138483214 @default.
- W2613597569 cites W2139325144 @default.
- W2613597569 cites W2140596923 @default.
- W2613597569 cites W2140714311 @default.
- W2613597569 cites W2145083591 @default.
- W2613597569 cites W2146473098 @default.
- W2613597569 cites W2147052402 @default.
- W2613597569 cites W2148033929 @default.
- W2613597569 cites W2149357894 @default.
- W2613597569 cites W2150757282 @default.
- W2613597569 cites W2152731121 @default.
- W2613597569 cites W2156410664 @default.
- W2613597569 cites W2160494819 @default.
- W2613597569 cites W2161371146 @default.
- W2613597569 cites W2163061133 @default.
- W2613597569 cites W2167717154 @default.
- W2613597569 cites W2171572418 @default.
- W2613597569 cites W2177560505 @default.
- W2613597569 cites W2186668366 @default.
- W2613597569 cites W2294291334 @default.
- W2613597569 cites W2333486152 @default.
- W2613597569 cites W2335583095 @default.
- W2613597569 cites W2343873789 @default.
- W2613597569 cites W2553971506 @default.
- W2613597569 cites W4234755708 @default.
- W2613597569 cites W4239183785 @default.