Matches in SemOpenAlex for { <https://semopenalex.org/work/W2613610912> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2613610912 abstract "Inhaled adenosine 5'-monophosphate (AMP)causesbronchoconstriction inatopic asthma, probably after invivoconversion toadenosine. Ithasbeensuggested thatadenosine potentiates preformed mediator release frommastcells on themucosal surface oftheairways by interacting withspecific purinoceptors, without affecting therelease ofnewly generated mediators. Theairway responseofninenon-atopic subjects asthma toinhaled AMP andthe influence oftheoral, selective H,histamine receptor antagonist terfenadine on this responsewas investigated. Thegeometric mean provocation concentrations ofhistamine andAMP required to produce a20%fall inFEVy(PC20) were1-82 and13mmol/l. Insubsequent placebo controlled time coursestudies theFEV,responsetoa single inhalation ofthePC20histamine was ablated after pretreatment with oral terfenadine 180 mg.This dose ofterfenadine caused an80%inhibition ofthe bronchoconstrictor responsetothePC20AMP whenmeasured astheareaunder thetime course- responsecurveandcompared with the responsetoPC20 AMPpreceded byplacebo. Terfenadine 600 mg failed toincrease protection against AMP further, butbothdoses ofterfenadine delayed thetime atwhich the mean maximumfall inFEV,after AMP wasachieved. Terfenadine 180 mg hadnoeffect onmethacholine induced bronchoconstriction inthe samesubjects. These datasuggest that inhaled AMP may potentiate therelease ofpreformed mediators frompreactivated mastcells inthebronchial mucosa ofpatients withintrinsic asthma." @default.
- W2613610912 created "2017-05-19" @default.
- W2613610912 creator A5029449735 @default.
- W2613610912 creator A5030571912 @default.
- W2613610912 creator A5054440034 @default.
- W2613610912 creator A5089020623 @default.
- W2613610912 date "2017-01-01" @default.
- W2613610912 modified "2023-10-11" @default.
- W2613610912 title "Effect oforal terfenadine onthebronchoconstrict or responsetoinhaled histamine andadenosine 5'-monophosphate innon-atopic asthma" @default.
- W2613610912 cites W2047163318 @default.
- W2613610912 cites W2076787462 @default.
- W2613610912 hasPublicationYear "2017" @default.
- W2613610912 type Work @default.
- W2613610912 sameAs 2613610912 @default.
- W2613610912 citedByCount "0" @default.
- W2613610912 crossrefType "journal-article" @default.
- W2613610912 hasAuthorship W2613610912A5029449735 @default.
- W2613610912 hasAuthorship W2613610912A5030571912 @default.
- W2613610912 hasAuthorship W2613610912A5054440034 @default.
- W2613610912 hasAuthorship W2613610912A5089020623 @default.
- W2613610912 hasConcept C110586980 @default.
- W2613610912 hasConcept C1122143 @default.
- W2613610912 hasConcept C126322002 @default.
- W2613610912 hasConcept C134018914 @default.
- W2613610912 hasConcept C142724271 @default.
- W2613610912 hasConcept C170493617 @default.
- W2613610912 hasConcept C185592680 @default.
- W2613610912 hasConcept C204787440 @default.
- W2613610912 hasConcept C2776042228 @default.
- W2613610912 hasConcept C2776711289 @default.
- W2613610912 hasConcept C2776885963 @default.
- W2613610912 hasConcept C2776954882 @default.
- W2613610912 hasConcept C2776991684 @default.
- W2613610912 hasConcept C2779303165 @default.
- W2613610912 hasConcept C2779876172 @default.
- W2613610912 hasConcept C2780769369 @default.
- W2613610912 hasConcept C2781018748 @default.
- W2613610912 hasConcept C42219234 @default.
- W2613610912 hasConcept C71924100 @default.
- W2613610912 hasConcept C98274493 @default.
- W2613610912 hasConceptScore W2613610912C110586980 @default.
- W2613610912 hasConceptScore W2613610912C1122143 @default.
- W2613610912 hasConceptScore W2613610912C126322002 @default.
- W2613610912 hasConceptScore W2613610912C134018914 @default.
- W2613610912 hasConceptScore W2613610912C142724271 @default.
- W2613610912 hasConceptScore W2613610912C170493617 @default.
- W2613610912 hasConceptScore W2613610912C185592680 @default.
- W2613610912 hasConceptScore W2613610912C204787440 @default.
- W2613610912 hasConceptScore W2613610912C2776042228 @default.
- W2613610912 hasConceptScore W2613610912C2776711289 @default.
- W2613610912 hasConceptScore W2613610912C2776885963 @default.
- W2613610912 hasConceptScore W2613610912C2776954882 @default.
- W2613610912 hasConceptScore W2613610912C2776991684 @default.
- W2613610912 hasConceptScore W2613610912C2779303165 @default.
- W2613610912 hasConceptScore W2613610912C2779876172 @default.
- W2613610912 hasConceptScore W2613610912C2780769369 @default.
- W2613610912 hasConceptScore W2613610912C2781018748 @default.
- W2613610912 hasConceptScore W2613610912C42219234 @default.
- W2613610912 hasConceptScore W2613610912C71924100 @default.
- W2613610912 hasConceptScore W2613610912C98274493 @default.
- W2613610912 hasLocation W26136109121 @default.
- W2613610912 hasOpenAccess W2613610912 @default.
- W2613610912 hasPrimaryLocation W26136109121 @default.
- W2613610912 hasRelatedWork W1515029751 @default.
- W2613610912 hasRelatedWork W1981193359 @default.
- W2613610912 hasRelatedWork W1987040353 @default.
- W2613610912 hasRelatedWork W1987611776 @default.
- W2613610912 hasRelatedWork W2009994511 @default.
- W2613610912 hasRelatedWork W2017989732 @default.
- W2613610912 hasRelatedWork W2047510261 @default.
- W2613610912 hasRelatedWork W2052970186 @default.
- W2613610912 hasRelatedWork W2065885340 @default.
- W2613610912 hasRelatedWork W2071710233 @default.
- W2613610912 hasRelatedWork W2128767780 @default.
- W2613610912 hasRelatedWork W2337594893 @default.
- W2613610912 hasRelatedWork W2396314883 @default.
- W2613610912 hasRelatedWork W2398939786 @default.
- W2613610912 hasRelatedWork W2412466152 @default.
- W2613610912 hasRelatedWork W2508377201 @default.
- W2613610912 hasRelatedWork W2533731043 @default.
- W2613610912 hasRelatedWork W2590475902 @default.
- W2613610912 hasRelatedWork W2610290608 @default.
- W2613610912 hasRelatedWork W2739997954 @default.
- W2613610912 isParatext "false" @default.
- W2613610912 isRetracted "false" @default.
- W2613610912 magId "2613610912" @default.
- W2613610912 workType "article" @default.