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- W2613646859 endingPage "137" @default.
- W2613646859 startingPage "137" @default.
- W2613646859 abstract "Prenatal alcohol exposure causes persistent neuropsychiatric deficits included under the term fetal alcohol spectrum disorders (FASD). Cellular identity emerges from a cascade of intrinsic and extrinsic (involving cell-cell interactions and signaling) processes that are partially initiated and maintained through changes in chromatin structure. Prenatal alcohol exposure influences neuronal and astrocyte development, permanently altering brain connectivity. Prenatal alcohol exposure also alters chromatin structure through histone and DNA modifications. However, the data linking alcohol-induced differentiation changes with developmental alterations in chromatin structure remain to be elucidated. In the first part of this review, we discuss the sequence of chromatin structural changes involved in neural cell differentiation during normal development. We then discuss the effects of prenatal alcohol on developmental histone modifications and DNA methylation in the context of neurogenesis and astrogliogenesis. We attempt to synthesize the developmental literature with the FASD literature, proposing that alcohol-induced changes to chromatin structure account for altered neurogenesis and astrogliogenesis as well as altered neuron and astrocyte differentiation. Together these changes may contribute to the cognitive and behavioral abnormalities in FASD. Future studies using standardized alcohol exposure paradigms at specific developmental stages will advance the understanding of how chromatin structural changes impact neural cell fate and maturation in FASD." @default.
- W2613646859 created "2017-05-19" @default.
- W2613646859 creator A5000185967 @default.
- W2613646859 creator A5015174459 @default.
- W2613646859 creator A5075306037 @default.
- W2613646859 creator A5090636372 @default.
- W2613646859 date "2017-05-11" @default.
- W2613646859 modified "2023-10-11" @default.
- W2613646859 title "Chromatin Switches during Neural Cell Differentiation and Their Dysregulation by Prenatal Alcohol Exposure" @default.
- W2613646859 cites W1499598203 @default.
- W2613646859 cites W1503960706 @default.
- W2613646859 cites W1521333964 @default.
- W2613646859 cites W1532048738 @default.
- W2613646859 cites W1532742668 @default.
- W2613646859 cites W1549972124 @default.
- W2613646859 cites W1555310782 @default.
- W2613646859 cites W1564786304 @default.
- W2613646859 cites W1605270587 @default.
- W2613646859 cites W1663062013 @default.
- W2613646859 cites W1841913343 @default.
- W2613646859 cites W1866504702 @default.
- W2613646859 cites W1878224612 @default.
- W2613646859 cites W1911064394 @default.
- W2613646859 cites W192756239 @default.
- W2613646859 cites W1935339094 @default.
- W2613646859 cites W1963675298 @default.
- W2613646859 cites W1965285944 @default.
- W2613646859 cites W1965425054 @default.
- W2613646859 cites W1965598953 @default.
- W2613646859 cites W1968035033 @default.
- W2613646859 cites W1968717432 @default.
- W2613646859 cites W1970697654 @default.
- W2613646859 cites W1971666902 @default.
- W2613646859 cites W1971779259 @default.
- W2613646859 cites W1971967959 @default.
- W2613646859 cites W1973398873 @default.
- W2613646859 cites W1974291993 @default.
- W2613646859 cites W1975231696 @default.
- W2613646859 cites W1977281942 @default.
- W2613646859 cites W1977690815 @default.
- W2613646859 cites W1977755031 @default.
- W2613646859 cites W1978195376 @default.
- W2613646859 cites W1978229870 @default.
- W2613646859 cites W1978500810 @default.
- W2613646859 cites W1979940429 @default.
- W2613646859 cites W1980730318 @default.
- W2613646859 cites W1981463058 @default.
- W2613646859 cites W1987182199 @default.
- W2613646859 cites W1988943763 @default.
- W2613646859 cites W1989457196 @default.
- W2613646859 cites W1989474078 @default.
- W2613646859 cites W1990356011 @default.
- W2613646859 cites W1990689143 @default.
- W2613646859 cites W1990849647 @default.
- W2613646859 cites W1992104052 @default.
- W2613646859 cites W1994514343 @default.
- W2613646859 cites W1994872818 @default.
- W2613646859 cites W1994974752 @default.
- W2613646859 cites W1995218219 @default.
- W2613646859 cites W1997184565 @default.
- W2613646859 cites W1997453048 @default.
- W2613646859 cites W1997652623 @default.
- W2613646859 cites W1997860363 @default.
- W2613646859 cites W1999194325 @default.
- W2613646859 cites W2001323469 @default.
- W2613646859 cites W2004321919 @default.
- W2613646859 cites W2004839314 @default.
- W2613646859 cites W2010843703 @default.
- W2613646859 cites W2014248877 @default.
- W2613646859 cites W2016024994 @default.
- W2613646859 cites W2017112724 @default.
- W2613646859 cites W2022542640 @default.
- W2613646859 cites W2025019063 @default.
- W2613646859 cites W2025329346 @default.
- W2613646859 cites W2026751327 @default.
- W2613646859 cites W2026776435 @default.
- W2613646859 cites W2028003321 @default.
- W2613646859 cites W2028148324 @default.
- W2613646859 cites W2033289257 @default.
- W2613646859 cites W2034948267 @default.
- W2613646859 cites W2035593289 @default.
- W2613646859 cites W2035697450 @default.
- W2613646859 cites W2037878697 @default.
- W2613646859 cites W2038439057 @default.
- W2613646859 cites W2039832624 @default.
- W2613646859 cites W2040323668 @default.
- W2613646859 cites W2040340635 @default.
- W2613646859 cites W2041028481 @default.
- W2613646859 cites W2041412314 @default.
- W2613646859 cites W2041486804 @default.
- W2613646859 cites W2041825762 @default.
- W2613646859 cites W2044567499 @default.
- W2613646859 cites W2044721366 @default.
- W2613646859 cites W2045979867 @default.
- W2613646859 cites W204659081 @default.
- W2613646859 cites W2046717651 @default.
- W2613646859 cites W2047246007 @default.
- W2613646859 cites W2048163917 @default.