FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2613654851> ?p ?o ?g. }

• W2613654851 endingPage "810" @default.
• W2613654851 startingPage "800" @default.
• W2613654851 abstract "Ceramide (CE), a bioactive lipid with tumor suppression, has been widely used as a drug carrier and enhancer for cancer therapy. CE-based combination therapy was prone to be attractive in cancer therapy. In our previous study, the combination of CE and docetaxel (DTX) was proved to be an effective strategy for cancer therapy. To further improve the antitumor efficiency of DTX, the CE lipid-based nanosuspensions (LNS) was prepared for the delivery of DTX to exhibit synergistic therapeutic effect. The enhanced delivery and synergistic therapeutic effect of DTX-loaded CE-LNS (CE + DTX-LNS) were evaluated. CE + DTX-LNS exhibited spherical or ellipsoidal shape, uniform particle size distribution (108.1 ± 3.8 nm), sustained release characteristics and good stability in vitro. Notably, CE + DTX-LNS could effectively co-localize CE and DTX into same tumor cell and subsequently play synergistic cell damage effect compared with CE-LNS + DTX-LNS (p < 0.05). The in vivo fluorescence imaging results showed that CE + DTX-LNS could effectively prolong the in vivo circulation time and enhance the accumulation in tumor sites. Moreover, the antitumor efficacy of CE + DTX-LNS observed in B16 murine melanoma model was 93.94 ± 2.77%, significantly higher than that of CE-LNS, DTX-LNS, Duopafei® (p < 0.01) and CE-LNS + DTX-LNS (p < 0.05), respectively, demonstrating that co-delivery of CE and DTX into same tumor cell was the basis for enhanced synergistic therapeutic effect. Furthermore, histological examination of Blank-LNS showed no visible tissue toxicity compared to normal saline. Consequently, CE-LNS could effectively delivery DTX and CE + DTX-LNS exhibit synergistic inhibition of tumor growth due to the co-localization of CE and DTX. CE-LNS hold great potential to be an appropriate carrier for CE-based combination chemotherapy." @default.
• W2613654851 created "2017-05-19" @default.
• W2613654851 creator A5042467158 @default.
• W2613654851 creator A5046941172 @default.
• W2613654851 creator A5055342281 @default.
• W2613654851 creator A5066226919 @default.
• W2613654851 creator A5074653520 @default.
• W2613654851 date "2017-01-01" @default.
• W2613654851 modified "2023-10-18" @default.
• W2613654851 title "Ceramide lipid-based nanosuspension for enhanced delivery of docetaxel with synergistic antitumor efficiency" @default.
• W2613654851 cites W1861336709 @default.
• W2613654851 cites W1972779095 @default.
• W2613654851 cites W1978271981 @default.
• W2613654851 cites W1980909702 @default.
• W2613654851 cites W1982420329 @default.
• W2613654851 cites W1986497256 @default.
• W2613654851 cites W1999736153 @default.
• W2613654851 cites W2000696450 @default.
• W2613654851 cites W2021101274 @default.
• W2613654851 cites W2021866663 @default.
• W2613654851 cites W2022490348 @default.
• W2613654851 cites W2028646432 @default.
• W2613654851 cites W2032474521 @default.
• W2613654851 cites W2038344662 @default.
• W2613654851 cites W2040071171 @default.
• W2613654851 cites W2044273547 @default.
• W2613654851 cites W2047548456 @default.
• W2613654851 cites W2053871805 @default.
• W2613654851 cites W2054462746 @default.
• W2613654851 cites W2055206644 @default.
• W2613654851 cites W2057030040 @default.
• W2613654851 cites W2060290219 @default.
• W2613654851 cites W2066484074 @default.
• W2613654851 cites W2066791556 @default.
• W2613654851 cites W2068581230 @default.
• W2613654851 cites W2082046754 @default.
• W2613654851 cites W2092451289 @default.
• W2613654851 cites W2095016306 @default.
• W2613654851 cites W2127625435 @default.
• W2613654851 cites W2151467658 @default.
• W2613654851 cites W2152352667 @default.
• W2613654851 cites W2184075064 @default.
• W2613654851 cites W2314380953 @default.
• W2613654851 cites W2342039381 @default.
• W2613654851 cites W2394272333 @default.
• W2613654851 cites W4296146232 @default.
• W2613654851 doi "https://doi.org/10.1080/10717544.2016.1225853" @default.
• W2613654851 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8241063" @default.
• W2613654851 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28502199" @default.
• W2613654851 hasPublicationYear "2017" @default.
• W2613654851 type Work @default.
• W2613654851 sameAs 2613654851 @default.
• W2613654851 citedByCount "16" @default.
• W2613654851 countsByYear W26136548512017 @default.
• W2613654851 countsByYear W26136548512018 @default.
• W2613654851 countsByYear W26136548512019 @default.
• W2613654851 countsByYear W26136548512020 @default.
• W2613654851 countsByYear W26136548512022 @default.
• W2613654851 countsByYear W26136548512023 @default.
• W2613654851 crossrefType "journal-article" @default.
• W2613654851 hasAuthorship W2613654851A5042467158 @default.
• W2613654851 hasAuthorship W2613654851A5046941172 @default.
• W2613654851 hasAuthorship W2613654851A5055342281 @default.
• W2613654851 hasAuthorship W2613654851A5066226919 @default.
• W2613654851 hasAuthorship W2613654851A5074653520 @default.
• W2613654851 hasBestOaLocation W26136548511 @default.
• W2613654851 hasConcept C121608353 @default.
• W2613654851 hasConcept C126322002 @default.
• W2613654851 hasConcept C150903083 @default.
• W2613654851 hasConcept C185592680 @default.
• W2613654851 hasConcept C190283241 @default.
• W2613654851 hasConcept C192562407 @default.
• W2613654851 hasConcept C207001950 @default.
• W2613654851 hasConcept C2777851122 @default.
• W2613654851 hasConcept C2781190966 @default.
• W2613654851 hasConcept C502942594 @default.
• W2613654851 hasConcept C55493867 @default.
• W2613654851 hasConcept C71924100 @default.
• W2613654851 hasConcept C86803240 @default.
• W2613654851 hasConcept C98274493 @default.
• W2613654851 hasConceptScore W2613654851C121608353 @default.
• W2613654851 hasConceptScore W2613654851C126322002 @default.
• W2613654851 hasConceptScore W2613654851C150903083 @default.
• W2613654851 hasConceptScore W2613654851C185592680 @default.
• W2613654851 hasConceptScore W2613654851C190283241 @default.
• W2613654851 hasConceptScore W2613654851C192562407 @default.
• W2613654851 hasConceptScore W2613654851C207001950 @default.
• W2613654851 hasConceptScore W2613654851C2777851122 @default.
• W2613654851 hasConceptScore W2613654851C2781190966 @default.
• W2613654851 hasConceptScore W2613654851C502942594 @default.
• W2613654851 hasConceptScore W2613654851C55493867 @default.
• W2613654851 hasConceptScore W2613654851C71924100 @default.
• W2613654851 hasConceptScore W2613654851C86803240 @default.
• W2613654851 hasConceptScore W2613654851C98274493 @default.
• W2613654851 hasIssue "1" @default.
• W2613654851 hasLocation W26136548511 @default.
• W2613654851 hasLocation W26136548512 @default.
• W2613654851 hasOpenAccess W2613654851 @default.

• next